254例糖尿病周围神经病变中医辨证分型及相关性研究

目的研究糖尿病周围神经病变患者的中医辨证分型与体重指数等指标的相关性。方法本研究共收集254例糖尿病患者的临床资料,依据糖尿病周围神经病变诊断标准分为有DPN组和无DPN组,再将DPN组患者按照2007版《糖尿病中医防治指南》糖尿病性周围神经病变辨证分型标准辨证分为4种证型:痰瘀内阻证、阴虚血瘀证、气虚血瘀证、肝肾亏虚证,对相关资料进行分型。结果 DPN组中阴虚血瘀型患者所占比例高于其他3个证型。气虚血瘀证和肝肾亏虚证的病程较阴虚血瘀证、痰瘀内阻证长。气虚血瘀证、肝肾亏虚证、痰瘀内阻证的体重指数和收缩压与阴虚血瘀证比较,差异均有统计学意义(P<0.05)。痰瘀内阻证的糖化血红蛋白、总胆固醇、低密度脂蛋白和空腹C肽较其他3证为高,差异有统计学意义(P<0.05)。气虚血瘀证、肝肾亏虚证的餐后2hC肽值与其他证型比较,差异有统计学意义(P<0.05)。结论阴虚血瘀是导致糖尿病周围神经病变发生的重要中医病机。阴虚血瘀型糖尿病周围神经病变患者相较于其他证型的糖尿病周围神经病变患者有体形相对消瘦、血压相对较低的特点。阴虚血瘀证和痰瘀内阻证病程较短,气虚血瘀证和肝肾亏虚证病程较长。

Diabetic peripheral neuropathy syndrome differentiation type of correlation patients

Objective Study on diabetic peripheral neuropathy in patients with TCM syndrome type and weight index correlation.Methods This study collected the clinical data of 254 cases of diabetic patients,based on the diagnosis of diabetic peripheral neuropathy standards are divided into DPN group and DPN group,the DPN group patients according to the 2007 edition of"traditional Chinese Medicine Diabetes Prevention Guide"for diabetic peripheral neuropathy syndrome differentiation standard of syndrome differentiation is divided into 4 patterns:phlegm stasis Yin deficiency,blood stasis,deficiency of Qi and blood stasis syndrome,liver and kidney deficiency syndrome,the data were typing.Results In DPN group of yin deficiency and blood stasis type with higher proportions of three other card type.Deficiency of Qi and blood stasis and liver and kidney deficiency syndrome in the patients with yin asthenia and blood stasis,syndrome of phlegm and blood stasis stasis long.The deficiency of Qi and blood stasis,syndrome of deficiency of liver and kidney,phlegm and blood stasis in body mass index and systolic blood pressure with yin asthenia and blood stasis had significant differences(P < 0.05).Phlegm and blood stasis of glycated hemoglobin,total cholesterol,low density lipoprotein and fasting C peptide than the other three certificates is high,the result was statistically significant(P < 0.05).Syndrome of deficiency of liver and kidney qi deficiency and blood stasis,postprandial 2 hours of C peptide and other syndromes had a significant difference(P < 0.05).Conclusion Yin asthenia and blood stasis is the cause of the occurrence of diabetic peripheral neuropathy of the important pathogenesis of traditional Chinese medicine.Yin deficiency and blood stasis type of diabetic peripheral neuropathy patients compared to other syndromes of diabetic peripheral neuropathy patients have relatively thin body,lower blood pressure characteristics.Syndrome of yin deficiency and blood stasis and phlegm stasis short duration,with Qi deficiency and blood stasis syndrome of deficiency of liver and kidney disease.