| 奥沙利铂神经毒性机制及防治研究进展 |
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| 引用本文： | 陈小兵,吕慧芳,陈贝贝,罗素霞. 奥沙利铂神经毒性机制及防治研究进展[J]. 中国医药科学, 2012, 0(3): 38-40 |
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| 作者姓名： | 陈小兵 吕慧芳 陈贝贝 罗素霞 |
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| 作者单位： | 郑州大学附属肿瘤医院;河南省肿瘤医院内科 |
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| 基金项目： | 河南省医药卫生重大攻关项目;卫生部科研基金资助项目(WKJ2011010012) |
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| 摘 要： | 奥沙利铂是第3代铂类抗癌药物,抗癌谱广、毒副反应轻微是其主要特点。但该药的外周神经毒性发生率却高达90%,是其剂量限制性毒性。现对奥沙利铂(乐沙定)神经毒性表现、分级、发生机制及防治策略进行综述,以便为奥沙利铂疗程持续和达到更好疗效、更小毒性提供依据。
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| 关 键 词： | 奥沙利铂 神经毒性 药物副作用 |
Oxaliplatin induced neurotoxicity:mechanism and therapy |
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| CHEN Xiaobing,LV Huifang,CHEN Beibei,LUO Suxia. Oxaliplatin induced neurotoxicity:mechanism and therapy[J]. China Medicine and Pharmacy, 2012, 0(3): 38-40 |
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| Authors: | CHEN Xiaobing LV Huifang CHEN Beibei LUO Suxia |
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| Affiliation: | Department of Internal Medicine,the Affiliated Cancer Hospital of Zhengzhou University,Henan Cancer Hospital,Zhengzhou 450008,China |
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| Abstract: | Oxaliplatin is the third generation of the platinum,is effective in the treatment of multiple solid tumors and also quite safe.However,there is a high incidence of peripheral neurotoxiciy,which is dose-limiting.In this article,the clinical manifestations,mechanism of neurotoxicity and therapy are reviewed to provide evidence in the efficacy and the safety of oxaliplatin for the continuous treatment of this disease. |
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| Keywords: | Oxaliplatin Neurotoxicity Side effect |
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