| 无创机械通气对急性心源性肺水肿患者脑钠素的影响 |
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| 引用本文： | 张国良,殷少军,吕中伟,傅佩芳,颜正茂,彭爱梅.无创机械通气对急性心源性肺水肿患者脑钠素的影响[J].同济大学学报(医学版),2008,29(6). |
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| 作者姓名： | 张国良 殷少军 吕中伟 傅佩芳 颜正茂 彭爱梅 |
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| 作者单位： | 1. 同济大学附属第十人民医院呼吸内科,上海,200072
2. 同济大学附属第十人民医院核医学科,上海,200072 |
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| 摘 要： | 目的评价无创机械通气（noninvasive ventilation，NIV）在急性心源性肺水肿抢救中的临床价值并观察治疗前后血浆脑钠素（brainnatriuretic peptide，BNP）水平的变化。方法急性心源性肺水肿合并低氧血症的患者46例，随机分为NIV治疗组（23例）和常规治疗组（23例）。常规治疗组为抗血小板、硝酸酯类药物、强心、利尿剂加用鼻导管给氧治疗。NIV治疗组。在常规内科治疗同时加用NIV治疗72h，分别观察治疗72h后两组患者心率、呼吸、血压、脉搏、血氧饱和度、血气分析和临床症状体征以及血浆BNP的变化。结果与常规治疗组比较，NIV组治疗72h后，患者临床症状与体征的改善明显，其SaO2、PaO2显著升高，HR、RR显著下降（P〈0．05或P〈0．01）。NIV治疗72h后血浆BNP水平显著降低（P〈0．01）。结论NIV治疗急性心源性肺水肿能迅速纠正缺氧、改善心功能，同时对神经内分泌亦有影响，可作为抢救急性心源性肺水肿的一种安全、有效的方法。
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| 关 键 词： | 无创通气 急性心源性肺水肿 低氧血症 脑钠素 |
Effects of NIV treatment on plasma concentration of BNP in patients with acute cardiogenic pulmonary edema |
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| ZHANG Guo-liang,YIN Shao-jun,LV Zhong-wei,FU Pei-fang,YAN Zheng-mao,PENG Ai-mei.Effects of NIV treatment on plasma concentration of BNP in patients with acute cardiogenic pulmonary edema[J].Journal of Tongji University(Medical Science),2008,29(6). |
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| Authors: | ZHANG Guo-liang YIN Shao-jun LV Zhong-wei FU Pei-fang YAN Zheng-mao PENG Ai-mei |
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| Institution: | ZHANG Guo-liang~1,YIN Shao-jun~1,LV Zhong-wei~2,FU Pei-fang~1,YAN Zheng-mao~1,PENG Ai-mei~1 (1.Dept.of Respiratory Medicine,Tenth People\' s Hospital,Tongji University,Shanghai 200072,China,2.Dept.of Nuclear Medicine,China) |
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| Abstract: | Objective To study the curative effects of noninvasive ventilation(NIV) in treating acute cardiogenic pulmonary edema(ACPE) and the influence of NIV on plasma brain natriuretic peptide(BNP) before and after treatment.Methods Forty-six patients with ACPE were randomly divided into NIV treatment group(n=23) and normal treatment group(n=23).Patients in normal treatment group was treated by routine therapy including giving anti-platelet,nitrates,cediland,diuretics drugs and supplying oxygen via nasal catheter.I... |
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| Keywords: | noninvasive ventilation acute cardiogenic pulmonary edema hypoxemia brain natriuretic peptide |
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