| 新型颈动脉再狭窄兔模型的建立 |
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| 引用本文： | 汝磊生,贾国良,李飞,李妍,张荣庆,李伟,徐凯. 新型颈动脉再狭窄兔模型的建立[J]. 心脏杂志, 2001, 13(4): 279-281. DOI: 10.13191/j.chj.2001.04.33.rulsh.013 |
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| 作者姓名： | 汝磊生 贾国良 李飞 李妍 张荣庆 李伟 徐凯 |
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| 作者单位： | 第四军医大学西京医院心内科,陕西,西安,710032 |
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| 摘 要： | 目的 :为了解再狭窄发生机制 ,进行再狭窄预防研究建立新西兰兔动物模型。方法 :采用直流电刺激的方法刺激兔颈总动脉外膜 ,在初步产生动脉纤维斑块的基础上 ,给予球囊扩张。结果 :通过血管造影及组织形态学观察 ,证实兔颈总动脉发生了动脉再狭窄病理改变。模型组血管腔内面积明显缩小 （P<0 .0 1） ,血管内膜增厚 （P<0 .0 1）。结论 :采用封闭群动物新西兰兔建立的颈总动脉狭窄模型具有模拟性好、死亡率低、实用性强和成功率高等优点
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| 关 键 词： | 颈总动脉 兔 再狭窄 模型 |
| 文章编号： | 1009-7236(2001)04-0279-03 |
| 修稿时间： | 2001-03-13 |
Establishment of a new restenosis model in carotid artery of rabbit |
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| RU Lei sheng,JIA Guo liang,LI Fei,LI Yan,ZHANG Rong qing,LI Wei,Xu Kai. Establishment of a new restenosis model in carotid artery of rabbit[J]. Chinese Heart Journal, 2001, 13(4): 279-281. DOI: 10.13191/j.chj.2001.04.33.rulsh.013 |
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| Authors: | RU Lei sheng JIA Guo liang LI Fei LI Yan ZHANG Rong qing LI Wei Xu Kai |
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| Abstract: | AIM:To establish an animal model to study the mechanism of restenosis for preventing and treating restenosis. METHODS:After induction of an intimal plaque in the right carotid artery by electrical stimulation,the rabbits underwent balloon angioplasty. RESULTS: By observation of the macrophages and angiography,we confirmed that the right carotid artery had the pathological changes of restenosis in the intervention group. CONCLUSION: For its adventages such as low mortality, high practicability and good reproduce, the model is an ideal model for study of the mechanism and the prevention of restenosis. |
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| Keywords: | carotid artery rabbit restenosis model |
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