大剂量纳洛酮持续微泵注入在重型颅脑损伤中的早期应用

目的观察早期大剂量应用纳络酮治疗重型颅脑损伤的临床效果。方法随机选取32例重型颅脑损伤病人作为治疗组,采用盐酸纳洛酮持续静脉点滴10天。对照组不使用盐酸纳洛酮。比较两组病人治疗10天后GCS评分及3个月后GOS评分。结果治疗10天后两组病人GCS评分,差异有统计学意义(P<0.05)。随访3个月后GOS评分,差异亦有统计学意义(P<0.05)。结论早期大剂量使用纳洛酮治疗重型颅脑损伤病人,可明显改善病人的预后,疗效确切。

Effection of High-dose Naloxne Administrated at the Early Stage on Severe Brain Injury

Objective To explore the influence of high-dose naloxone administrated at the earlystage on severe brain injury.Methods 32 patients with severe craniocerebral injury were randomly chosen as intervention group.Naloxone hydrochloride was infused intravenously for 10 days.No naloxone hydrochloride was given to control group.The scores of GCS after 10 days and GOS after 3 months of the two groups were compared.Results There was significant difference in GCS scores after 10 days of treatment between the two groups (P < 0.05) and extremely significant difference in GOS scores after 3 months of treatment (P < 0.05).Conclusion Early administration of large dose of naloxone hydrochloride can achieve a favorable effect and considerably ameliorate prognosis for patients with severe cranlocerebral injury.