Association between atopy and recurrent vaginal candidiasis |
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Authors: | Neves N A Carvalho L P De Oliveira M A M Giraldo P C Bacellar O Cruz A A Carvalho E M |
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Institution: | Servi?o de Imunologia, Hospital Universitario Prof Edgard Santos, Universidade Federal da Bahia, Salvador, Bahia, Brazil. |
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Abstract: | To determine whether there is an association between atopy and recurrent vaginal candidiasis (RVC) and to evaluate the type-2 immune response in patients with RVC. Evaluation of immediate hypersensitivity skin tests to aeroallergens, measurement of total IgE and Candida albicans specific IgE and levels of IL-5 in 44 women with RVC and 26 with sporadic vaginal candidiasis (SVC). Statistical analyses were performed by Mann-Whitney test and chi(2) test with Yates correction. History of atopy (68%) and positive skin test (42%) were higher (P < 0.05) in RVC than in patients with SVC. No significant difference was found in total IgE, C. albicans specific IgE and IL-5 levels. There was a strong association between atopy and RVC, but type-2 immune response to C. albicans antigen was absent or similar in the two groups of patients. |
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Keywords: | recurrent vaginal candidiasis immune regulation atopy cytokines IgE |
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