| 血管内皮生长因子基因3'-非翻译区C936T多态性与2型糖尿病肾病相关 |
| |
| 引用本文： | 张新焕,郭颖,陈黎红,丁鹤林,傅祖植.血管内皮生长因子基因3'-非翻译区C936T多态性与2型糖尿病肾病相关[J].中华内分泌代谢杂志,2008,24(3). |
| |
| 作者姓名： | 张新焕 郭颖 陈黎红 丁鹤林 傅祖植 |
| |
| 作者单位： | 1. 泰山医学院附属医院内分泌科,271000
2. 中山大学附属第二医院内分泌科,广州,510120 |
| |
| 基金项目： | 广东省科技技术资助项目，广东省科技厅科技计划 |
| |
| 摘 要： | 采用PCR-RFLP方法分析了194例2型糖尿病患者血管内皮生长因子(VECF)基因3'-非翻译区C936T变异与糖尿病肾病的关系.发现糖尿病肾病组C等位基因及CC基因型频率显著高于非肾病组和正常对照组,提示C等位基因及CC基因型患者可能是糖尿病易于发生肾病危险性的遗传标志.
|
| 关 键 词： | 血管内皮生长因子 多态性 单核苷酸 糖尿病 2型 糖尿病肾病 |
C936T polymorphism in 3'-untranslated region of vascular endothelial growth factor gene is associated with diabetic nephropathy in type 2 diabetics |
| |
| ZHANG Xin-huan,GUO Ying,CHEN Li-hong,DING He-lin,FU Zu-zhi.C936T polymorphism in 3'-untranslated region of vascular endothelial growth factor gene is associated with diabetic nephropathy in type 2 diabetics[J].Chinese Journal of Endocrinology and Metabolism,2008,24(3). |
| |
| Authors: | ZHANG Xin-huan GUO Ying CHEN Li-hong DING He-lin FU Zu-zhi |
| |
| Abstract: | The relationship between C936T polymorphism at 3'-untranslated region of vascular endothelial growth factor (VEGF) gene and diabetic nephropathy (DN) was analysed in 194 type 2 diabetic patients. The frequencies of genotype CC and allele C were significantly higher in DN group than those in non-DN group and control group. Allele C and genotype CC of VEGF may be a genetic marker susceptible to DN. |
| |
| Keywords: | Vascular endothelial growth factor Polymorphism single nucleotide Diabetes mellitus type 2 Diabetic nephropathies |
| 本文献已被 万方数据 等数据库收录！ |
