| 用单克隆抗体检测SLE患者IL－2及IL－6分泌细胞量 |
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| 引用本文： | 孙梦晖,殷志伟,冯树一,周珏伟,杨晓慧.用单克隆抗体检测SLE患者IL－2及IL－6分泌细胞量[J].临床皮肤科杂志,1996(6). |
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| 作者姓名： | 孙梦晖 殷志伟 冯树一 周珏伟 杨晓慧 |
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| 作者单位： | 苏州医学院病理生理教研室，苏州医学院第一附属医院皮肤科 |
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| 基金项目： | 江苏省科学技术委员会资助 |
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| 摘 要： | ＩＬ－２和ＩＬ－６是机体重要的免疫调节因子。采用单克隆抗体以免疫酶标技术（ＡＰＡＡＰ法）对不同病期ＳＬＥ患者外周血单个核细胞中的ＩＬ－２、ＩＬ－６分泌细胞量进行了检测。结果表明：与正常人比较，活动期患者ＩＬ－２、ＩＬ－６分泌细胞量均升高（Ｐ＜０．０１），且二者间具相关性（ｒ＝０．８８，Ｐ＜０．０５）；非活动期患者ＩＬ－２分泌细胞量升高（Ｐ＜０．０１）而ＩＬ－６分泌细胞量与正常接近。
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| 关 键 词： | 系统性红斑狼疮 白细胞介素 |
Detection of IL-2 and IL-6 producer cells with monoclonal antibodies in SLE patients |
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| Sun Menghui,Yin Zhiwei,Feng Shuyi,et al.Detection of IL-2 and IL-6 producer cells with monoclonal antibodies in SLE patients[J].Journal of Clinical Dermatology,1996(6). |
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| Authors: | Sun Menghui Yin Zhiwei Feng Shuyi |
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| Abstract: | The IL-2 and IL-6 are important immunomodulating factors of our body.By using monoclonal antibodies and immunoenzyme labelling technique(APAAP method),the IL-2 and IL-6 producer cells were detected in peripheral blood mononuclear cells from patients with active and inactive SLE. The results showed that both of the IL-2 and IL-6 producer cells are significantly increased in patients with active SLE compared with normal(P<0.0 1). They also had positive correlation (r= 0. 88, P<0. 05). In inactive SLF , the number of IL-2 producer cells are higher than that of normal ones while the number of IL-6 producercells did not show difference to controls. |
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| Keywords: | SLE Interleukins |
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