实验性肥胖大鼠药物减肥研究

 目的 研究胰高血糖素样肽-1受体激动剂(Exendin-4)对营养性肥胖大鼠的减肥作用.方法 建立营养性肥胖动物模型,然后将40只肥胖模型大鼠,随机分成4个组,分别为3个实验组(高、中、低3个剂量组)和1个对照组.连续给药9周,记录体重、摄食量,并检测血清胆固醇、三酰甘油、睾丸脂肪重量和细胞大小.结果 用药后高剂量组大鼠体重增长缓慢,睾丸周围脂肪重量与对照组相比明显降低,差异有统计学意义.而摄食量、血清胆固醇、三酰甘油、脂肪细胞大小不受药物的影响.其他各组与对照组比较差异无统计学意义.结论 Exendin-4长期皮下给药,对肥胖大鼠具有明确的延缓体重增长的效果.

Eexperimental study of exendin-4 for weight reduction in obese rats

Objective To study the effect of exendin-4 on weight reduction in obese rats after long-term subcutaneous injection.Methods Obesity rat model was developed by feeding food of high fat.Forty obese rats were randomly assigned to three experimental groups and one control group.The experimental groups were injected subcutaneously with exendin-4 in high,medium,and low doses,respectively,for 9 weeks.Body weight,food consumption,cholesterol,triglyceride,testicular fat pad weight,and diameter of adipocytes were measured.Results Body weight and fat pad weight in high dose group were significantly lower than those in control group(P<0.05).There were no statistically significant differences in food consumption,serum cholesterol,serum tricyleride and lipocytesize between high dose group and control group.Conclusion Long-term subcutaneous injection high dose exendin-4 slows weight gain in obese rats.