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| 携带血管抑素K1-5基因的腺病毒载体对血管内皮细胞增殖的抑制作用 | |
| 引用本文： | 刘恩令,周玉秀,糜若然,钱其军.携带血管抑素K1-5基因的腺病毒载体对血管内皮细胞增殖的抑制作用[J].实用癌症杂志,2008,23(1):15-17. |
| 作者姓名： | 刘恩令 周玉秀 糜若然 钱其军 |
| 作者单位： | 1. 河北医科大学附属唐山工人医院妇产科,063000 2. 天津医科大学总医院妇产科,300052 3. 第二军医大学东方肝胆病医院基因与病毒治疗中心,200433 |
| 摘 要： | 目的 研究携带血管抑素K1-5基因的腺病毒载体对其对血管内皮细胞增殖的抑制作用.方法 采用直接感染台盼蓝染色排除法、MTT实验检测血管抑素K1-5对血管内皮细胞增殖的抑制作用.结果 直接感染台盼蓝染色排除法及MTT法检测表明,携带血管抑素K1-5基因的腺病毒能显著抑制血管内皮细胞增生,并对其具有杀伤力.结论 血管抑素K1-5能明显抑制血管内皮细胞增殖,为进一步体内实验,研究其对血管形成的抑制作用奠定了基础. |
| 关 键 词： | 血管抑素K1-5 腺病毒载体 人脐静脉血管内皮细胞 抑制作用 血管抑素 基因 毒载体 血管内皮细胞增殖 抑制作用 Gene Angiostatin Adenovirus Vector Vascular Endothelial Cells Human Proliferation Suppression Function 血管形成 体内实验 杀伤力 血管内皮细胞增生 病毒 实验检测 结果 |
| 文章编号： | 1001-5930（2008）01-0015-03 |
| 收稿时间： | 2007-04-27 |
| 修稿时间： | 2007-10-19 |
The Study of the Function of Suppression to Proliferation for Human Vascular Endothelial Cells of Adenovirus Vector with Angiostatin K1-5 Gene |
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| LIU En-ling, ZHOU Yu-xiu, MI Ruo-ran,et al..The Study of the Function of Suppression to Proliferation for Human Vascular Endothelial Cells of Adenovirus Vector with Angiostatin K1-5 Gene[J].The Practical Journal of Cancer,2008,23(1):15-17. | |
| Authors: | LIU En-ling ZHOU Yu-xiu MI Ruo-ran |
| Institution: | LIU En-ling, ZHOU Yu-xiu, MI Ruo-ran, et al. |
| Abstract: | Objective To investigate the suppression effects of a adenovirus vector containing angiostatin K1-5 gene to the proliferation and migration of vascular endothelial ceils. Methods In vitro vascular endothelial cell proliferation was investigated through direct infection and MTT assay. Results Through direct infection and MTT assay,we found that adenovirus vector containing angiostatin K1-5 could inhibit the proliferation of human vascular endothelial cells. Conclusion Adenovirus vector containning angiostatin K1-5 could inhibit the proliferation of human vascular ceils. This could be served as a basis for further in vivo studies. |
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