Occupational risks for uveal melanoma results from a case-control study in nine European countries |
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| Authors: | Jean-Michel Lutz Ian Cree Svend Sabroe Tine Kajsa Kvist Lene Bjørk Clausen Noemia Afonso Wolfgang Ahrens Terri J. Ballard Janine Bell Diane Cyr Mikael Eriksson Joëlle Févotte Pascal Guénel Lennart Hardell Karl-Heinz Jöckel Ana Miranda Franco Merletti Maria M. Morales-Suarez-Varela Aivars Stengrevics Elsebeth Lynge |
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| Affiliation: | (1) Registre Genevois des Tumeurs, Geneva, Switzerland;(2) Queen Alexandra Hospital, Translational Oncology Research Centre, Portsmouth, UK;(3) Department of Epidemiology and Social Medicine, University of Aarhus, Denmark;(4) Institute of Public Health, University of Copenhagen, Blegdamsvej 3, DK 2200 København N, Denmark;(5) Serviço de Bioestatística e Informática Médica, Al. Hernani Monteiro, Porto, Portugal;(6) Bremen Institute for Prevention Research and Social Medicine, Bremen, Germany;(7) The Venetian Tumour Registry, Padua, Italy;(8) Thames Cancer Registry, London, UK;(9) INSERM Unité 88, Saint Maurice, France;(10) Department of Oncology, University Hospital, Lund, Sweden;(11) Institut Universitaire de Médecine du Travail, Université Claude Bernard, Lyon, France;(12) INSERM Unité 170, Villejuif, France;(13) Department of Oncology, University Hospital, Örebro, Sweden;(14) Institute for Medical Informatics, Biometry and Epidemiology, University Clinics of Essen, Germany;(15) Instituto Portuquès de Oncologia de Francisco Gentil, Lisboa, Portugal;(16) Unit of Cancer Epidemiology, University of Turin, CERMS and CPO, Piemonte, Italy;(17) Unit of Public Health, Valencia University, Dr. Peset University Hospital, Spain;(18) Latvia Cancer Register, Latvia Oncology Centre, Riga, Latvia |
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| Abstract: | Objective Uveal melanoma is a rare disease with poor prognosis and largely unknown etiology. We studied potential occupational risk factors.Methods A population based case-control study was undertaken during 1995–1997 in nine European countries using population and colon cancer controls with personal interviews. Occupational exposure to sunlight and artificial UV radiation was assessed with a job exposure matrix. In total, 320 uveal melanoma cases were eligible at pathology review, and 292 cases were interviewed, participation 91%. Out of 3357 population controls, 2062 were interviewed, 61%, and out of 1272 cancer controls 1094 were interviewed, 86%.Results Using population controls, occupational exposure to sunlight was not associated with an increased risk (RR=1.24, 95% CI=0.88−1.74), while an excess risk found with use of colon cancer controls was attributed to confounding factors. An excess risk in welders was restricted to the French part of the data. Cooks, RR=2.40; cleaners, RR 2.15; and laundry workers, RR=3.14, were at increased risk of uveal melanoma.Conclusion Our study does overall not support an association between occupational sunlight exposure and risk of uveal melanoma. The finding of an excess risk of eye melanoma in cooks in several European countries is intriguing. |
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| Keywords: | case-control study eye Malignant melanoma |
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