| 酚酸类化合物体外抗血小板聚集活性探讨 |
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| 引用本文： | 刘岱琳 丁光荣. 酚酸类化合物体外抗血小板聚集活性探讨[J]. 沈阳药科大学学报, 1998, 15(1): 25-28 |
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| 作者姓名： | 刘岱琳 丁光荣 |
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| 作者单位： | 沈阳药科大学中药系!沈阳 110015(刘岱琳，王乃利)，抚顺市医药局药政处(王欣)，第四铁路工程局中心医院药剂科!合肥 230023(丁光荣)，辽宁省医药工业研究院(王家相)，沈阳市职工医学院!沈阳 110001(陈宁) |
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| 摘 要： | 通过对１９种酚酸类化合物体外抗 ＡＤＰ诱导兔血小板聚集活性的测定，探讨了体外抗凝血的构效关系．邻三酚羟基的酚酸比邻二酚羟基的酚酸活性强；而脂肪二酸类比酚酸类化合物的活性高；甲氧基取代的酚酸类化合物抗血小板聚集活性明显增高．
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| 关 键 词： | 血小板聚集 没食子酸 酚酸类化合物 |
An Inquiry of Activities of Phenolic Acids against the Aggregation of Rabbit Platelet in vitro |
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| Liu Dailin,Ding Guangrong,Chen Ning,Wang Xin,Wang Naili,Wang Jiaxiang. An Inquiry of Activities of Phenolic Acids against the Aggregation of Rabbit Platelet in vitro[J]. Journal of Shenyang Pharmaceutical University, 1998, 15(1): 25-28 |
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| Authors: | Liu Dailin Ding Guangrong Chen Ning Wang Xin Wang Naili Wang Jiaxiang |
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| Abstract: | Nineteen compounds were inquiried of structure-activity relationship of anticoagulation activities by means of bioassay against ADP induced aggregation of rabbit platelet in vitro. o-3-Phenolic acids and di-fatty acids manifested stronger activities than those of o-2-Phenolic acids and phenolic acids. Furthermore, methoxyl phenolic acids exhibited obvious activities. |
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| Keywords: | aggregation of rabbit platelet gallic acid phenolic acids |
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