利培酮替换氯氮平治疗精神分裂症临床研究

目的：探索以利培酮替换氯氮平的临床换药方法。方法：受试患者随机进入3组；单用利培酮组，利培酮＋安坦组，利培酮＋阿普唑仑组，在治疗前、治疗后1、2、4、6周用阳性症状与阴性症状量表达（PANSS)、体外系副反应量表（ESRS）、不良反应症状量表（TESS）比较其疗效和副反应。结果：3组换药后疗效均显著（P＜0．01），3组间无显著差异（P＞0．05）。女性较男性副反应大一些，利培酮＋阿普唑仑组副反应最轻，单用利培酮组副反应最大，结论：利培酮＋阿普唑仑替换氯氮平方案较佳。

A clinical study on substitution of risperidone for clozapine in the treatment of schizophrenia

Objective:To explore a clinical optimal regime of substituting risperidone for clozapine. Method:Subjects were randomly enrolled into three groups: risperidone group, combination of risperidone and benzhexol group and combination of risperdone and alprazolam group. The efficacy and side effects were accessed with the positive and negative symptom scale (PANSS), a rating scale for extramidal side effects (ESRS) and the treatment emergent symptom scale (TESS) before and after treatment. Results:The efficacy of all regimes was significant, and no significant differences were found among them. The female patients had more severe side effects than the male patients. The side effects were slightest in the combination of risperidone and alprazolam group and most severe in the risperidone group. Conclusion:Substituting risperidone and alprazolam for clozapine is the optimal regime in the treatment of schizophrenia.