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Drug-induced liver injury after allogeneic bone marrow transplantation |
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| Authors: | Takayoshi Tachibana Akito Nozaki Makiko Enaka Eri Yamamoto Rika Kawasaki Hideyuki Koharazawa Maki Hagihara Daisuke Ishibashi Yuki Nakajima Hideyuki Kuwabara Naoto Tomita Yoshiaki Ishigatsubo Shin Fujisawa |
| Affiliation: | 1. Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan 3. Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan 2. Department of Transfusion Medicine, Yokohama City University Medical Center, Yokohama, Japan 4. Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan |
| Abstract: | A 23-year-old woman developed acute severe hepatitis and jaundice on day 183 after bone marrow transplantation from HLA-B antigen mismatched-related donor. The administration of prednisolone and cessation of the prescribed drugs resolved the liver injury. Drug lymphocyte stimulation test was positive for acyclovir, and liver biopsy indicated the characteristics of drug-induced liver injury (DILI) rather than graft-versus-host disease. Physicians should keep DILI in mind when considering differential diagnosis for liver complications after allogeneic cell transplantation. |
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