|
|||||
|
|
Kainate Receptor RNA Editing is Markedly Altered by Acute Spinal Cord Injury |
|
| Authors: | Luca Caracciolo Fabio Fumagalli Stephana Carelli Laura Madaschi Luca La Via Daniela Bonini Chiara Fiorentini Sergio Barlati Alfredo Gorio Alessandro Barbon |
| Affiliation: | 1. Division of Biology and Genetics, Department of Molecular and Translational Medicine and National Institute of Neuroscience, University of Brescia, Viale Europa 11, 25123, Brescia, Italy 2. Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy 3. Laboratory of Pharmacology, Department of Health Sciences, Faculty of Medicine, University of Milan, Via A. di Rudinì 8, 20142, Milan, Italy 4. Division of Pharmacology and Toxicology, Department of Molecular and Translational Medicine and National Institute of Neuroscience, University of Brescia, Viale Europa 11, 25123, Brescia, Italy 5. Division of Biology and Genetics, Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123, Brescia, Italy |
| Abstract: | We have previously observed changes in the RNA editing of AMPA receptors after acute spinal cord injury (SCI); this implies that post-transcriptional modifications are capable of affecting the physiological properties of glutamate receptor channels and related signal transduction in this neurodegenerative condition. Here, we report that the editing of the ionotropic KAR is markedly decreased at both GluK1 and GluK2 Q/R sites in the epicenter of the lesion and with distinct magnitude and kinetics also in the caudal and rostral portions of the injured cord. These effects are persistent, being observed as late as 30 days after lesioning. In addition, also the I/V and Y/C sites of GluK2 were severely affected after SCI. These findings add novel information to the relevance of editing of glutamate receptors following acute SCI, thus expanding the recently emerged role of post-transcriptional mechanisms under these experimental conditions. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |