SEROTONIN IS REDUCED IN THE FRONTAL CORTEX OF SARDINIAN ETHANOL-PREFERRING RATS |
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| Authors: | DEVOTO, PAOLA COLOMBO, GIANCARLO STEFANINI, ENNIO GESSA, GIAN LUIGI |
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| Affiliation: | ‘Bernard B. Brodie’ Department of Neuroscience, University of Cagliari via Porcell 4, 1-09124 Cagliari, Italy
1C.N.R. Centre for Neuropharmacology Cagliari, Italy |
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| Abstract: | Ethanol-naive Sardinian alcohol-preferring (sP) and Sardinianalcohol-non-preferring (sNP) rats were tested to evaluate thelevels of serotonin (5-HT) and 5-hydroxyindol-3-yl-acetic acid(5-HIAA) in the frontal cortex, hypothalamus, and nucleus accumbens,and the levels of dopamine (DA) and 3,4-dihydroxyphenylaceticacid (DOPAC) in the hypothalamus and nucleus accumbens. Comparedwith the sNP line, the sP rats had lower 5-HT and 5-HIAA concentrationsin the frontal cortex, whereas no differences were found inthe other brain areas tested, neither for neurotransmittersnor their metabolites. As the decreased 5-HT function is a featureshared by different alcohol-preferring strains, it could belinked to the genetic predisposition to voluntary ethanol consumption. |
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