骨桥蛋白与结直肠癌及肝转移关系研究进展 |
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引用本文: | 吕远,李世拥,安萍等.骨桥蛋白与结直肠癌及肝转移关系研究进展[J].中华普外科手术学杂志(电子版),2014(2):178-180. |
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作者姓名: | 吕远 李世拥 安萍等 |
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作者单位: | 解放军北京军区总医院普通外科 全军普通外科中心, 北京100700 |
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基金项目: | 国家自然科学基金资助项目(30772118,81041025) |
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摘 要: | 骨桥蛋白( OPN)是一种具有分泌性、粘附性的磷酸化的酸性糖蛋白,因其在多个肿瘤的发生发展和转移过程中密切相关,被称为肿瘤相关性蛋白。骨桥蛋白通过调节肿瘤细胞的黏附、迁移和刺激周围血管的生成,促进肿瘤侵袭和转移。研究证实,骨桥蛋白可作为结直肠癌发生和肝转移良好的诊断标记,是肿瘤免疫治疗的新靶点。通过总结OPN结构、功能及作用机制,对骨桥蛋白与结直肠癌发生和肝转移的相关性研究展开综述。
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关 键 词: | 骨桥蛋白质 结直肠肿瘤 肿瘤转移 综述 |
Research Progress of Osteopontin and Its Correlation with Colorectal Cancer and Liver Metastasis |
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Authors: | Lyu Yuan Li Shiyong An Ping Cai Huiyun |
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Institution: | ( Department of General Surgery, General Surgery Center of PL4, General Hospital of Beijing Military Command, Beijing 100700, China) |
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Abstract: | Osteopontin ( OPN) , a tumor associated protein , is a secreted adhesive phosphorylated glycoprotein which is closely related to tumorigenesis and metastasis .OPN not only plays important roles in the adhesion and immigration of tumor cells , but also in the angiogenesis , all of which could enhance the invasion and metastasis of tumor .Accumulated data confirmed that OPN is a diagnostic marker to colorectal cancer and liver metastasis , and OPN might be a new therapeutic target for tumor immunotherapy .This paper reviewed the structure , biological fuction and mechanism of OPN , and summarized current progress related to OPN and colorectal cancer and liver metastasis . |
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Keywords: | Osteopontin Colorectal neoplasms Neoplasm metastasis Review |
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