| 同型半胱氨酸和胱硫醚-β合成酶基因多态性与脑梗死的关系 |
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| 引用本文： | 杜为强,王孝杰,陈光荣,谢云庆,陈盛强.同型半胱氨酸和胱硫醚-β合成酶基因多态性与脑梗死的关系[J].现代医院,2009,9(2):10-12. |
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| 作者姓名： | 杜为强 王孝杰 陈光荣 谢云庆 陈盛强 |
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| 作者单位： | 1. 佛山市高明区人民医院,广东佛山,528500
2. 广州医学院神经科学研究所,广东广州,510260 |
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| 基金项目： | 佛山市卫生局科技项目 |
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| 摘 要： | 目的探讨同型半胱氨酸(Hcy)和胱硫醚-β合成酶(CBS 844ins 68)基因多态性与脑梗死的关系。方法运用多聚酶链反应技术和荧光偏振法(FPIA)检测75例脑梗死及143例正常人CBS 844ins 68基因多态性和血浆总Hcy水平。结果①脑梗死组CBS844ins 68 D/D、D/I、I/I基因型频率(%)分别为80.00、17.33、2.67,对照组分别为78.32、18.88、2.8,CBS844ins 68各种基因型频率在患者组与正常对照组之间的无显著性差异(p>005)。②脑梗死组与对照组血浆Hcy分别为(13.6±5.4)μmol/L和(10.9±2.4)μmol/L,两者有显著性差异(p<0.05)。脑梗死患者血浆总Hcy水平显著高于正常组。结论胱硫醚-β合成酶多态性与脑梗死无明显相关,高同型半胱氨酸血症与脑梗死发生有一定关系。
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| 关 键 词： | 脑梗死 胱硫醚-β合成酶 多态性 |
THE RELATIONSHIP OF POLYMORPHISM OF METHIONE SYNTHASE GENE(CBS844INS 68)AND PLASMA HOMOCYSTEINE LEVEL WITH CEREBRAL INFARCTION |
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| Institution: | DU Weiqiang , WANG Xiaojie , CHEN Guangrong , et al(People＇s Hospital of Gaoming District of Foshan City, Foshan, Guangdong Province 528500 PRC) |
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| Abstract: | Objective To explore the relationship of polymorphism of cystathionine B - synthase gene （ CBS 844ins 68） and plasma homocysteine level with cerebral infarction. Methods The genotyes of cystathionine B - synthase were determined by PCR - based assay and their plasma homocysteine levels were determined using FPIA method in 75 patients with cerebral infarction and 143 healthy controls. Results （1）There were no significant differences in the frequenceies of cystathionine B -synthase mutations between the patients and control group （p 〉 0. 05 ）. （2） Mean total plasma homocysteine concentrations were significantly higher in cerebral infarction patients than in the normal subjects. Conclusion Cystathionine B - synthase may not be independent risk factors for cerebral infarction and hyperhomocysteinemia may be independent risk factors for cerebral infarction. |
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| Keywords: | Cerebral infarction cystathionine B -synthase Homocysteine Polymorphism |
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