| 用离体灌注大鼠肾观察血管内皮依赖性舒张因子与环孢霉素A的肾毒作用 |
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| 引用本文： | 刘必成,林善锬,程颖,顾亚明,卢佩芳,郝传明. 用离体灌注大鼠肾观察血管内皮依赖性舒张因子与环孢霉素A的肾毒作用[J]. 复旦学报(医学版), 1993, 0(6) |
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| 作者姓名： | 刘必成 林善锬 程颖 顾亚明 卢佩芳 郝传明 |
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| 作者单位： | 南京铁道医学院附属医院肾病科(刘必成)，上海医院大学华山医院肾病科(林善锬，顾亚明)，中国人民解放军八五医院内科(程颖，卢佩芳)，上海医院大学华山医院肾病科(郝传明) |
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| 基金项目： | 纽约中华医学基金会，自然科学基金赞助 |
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| 摘 要： | 作者在大鼠离体灌注肾中(IPK)观察乙酰胆碱(Ach)和硝酸甘油(GTN)对环孢霉素A(CsA)所致血流动力学改变的影响。结果表明:GTN可改善由CsA所致的肾血浆流量(RPF)、肾小球滤过率(GFR)、尿量(UV)、滤过分数(FF)的下降以及肾血管阻力(RVR)的增高,而Ach对该药作用后的IPK上述指标无影响。由干Ach所致血管舒张为内皮细胞依赖性,因此CsA致内皮细胞受损,内皮由来性舒张因子(EDRF)释放减少可能与CsA的急性肾脏缩血管作用有关。
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| 关 键 词： | 离体灌注肾 内皮由来性舒张因子 环孢霉素A肾毒作用 |
CYCLOSPORINE A INDUCED ABNORMAL RESPONSE OF ENDOTHELIUM DEPENDENT RELAXATION ON ISOLATED PERFUSED RAT KIDNEY |
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| Bi-Cheng,Lin San-Yan,Chen Yin,Lu Pel-Fang,Hao Ohuan-Ming. CYCLOSPORINE A INDUCED ABNORMAL RESPONSE OF ENDOTHELIUM DEPENDENT RELAXATION ON ISOLATED PERFUSED RAT KIDNEY[J]. Fudan University Journal of Medical Sciences, 1993, 0(6) |
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| Authors: | Bi-Cheng Lin San-Yan Chen Yin Lu Pel-Fang Hao Ohuan-Ming |
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| Abstract: | The aim of this study was to use a Oyclosporine A (OsA) induced acute IPK hemodynamic disturbance model to study the responses of IPK to endothelium dependent relaxtor acetyl-choline(Ach) and non-endothelium dependent relaxtor glyceryl trinitrate(GTN)after exposure to OsA.The results showed: GTN significantly improved OsA induced increas of RVR, and decrease of RPF, GFR, UV and FF of IRK, while no response was observed after Ach use in this model. These preliminary results suggest that injurious endothelial release of decreased EDRF be involved in OsA induced acute nephrotoxicity in IPK. |
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| Keywords: | isolated perfused kidney (IPK) endothelium derived relaxing factor (EDEF) oyclosporine A(CsA) nephrotoxicity |
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