复发性流产病因学研究进展

复发性流产（recurrent spontaneous abortion, RSA）一般指与同一配偶发生连续３次或３次以上的自然流产。近年来许多学者提出将连续发生2次的自然流产者纳入RSA的范畴，原因是连续发生2次自然流产后，再次妊娠的流产率可高达50%以上，要引起足够的重视。RSA的病因复杂，目前已知的病因有染色体异常、生殖道解剖异常、内分泌失调、感染性疾病因素、血栓前状态、自身免疫因素等。除此之外，临床上仍有至少40%以上的患者病因不明。由于RSA的病因复杂，造成了RSA的难治性，是目前基础与临床研究的难点与热点。

The etiology of recurrent spontaneous abortion research.

Abstract：Recurrent spontaneous abortion (RSA) is defined as the occurrence of three or more consecutive abortions with the same partner. Scholars in recent years have proposed that two consecutive spontaneous miscarriages should be included in the scope of RSA, because the abortion risk for future pregnancy is up to 50%,the clinical manifestation should be paid more attentionnow. RSA is a complex multifactorial problem associated with chromosome, reproductive tract anatomic, endocrinologic, infection, immune etiologies and pre-thrombotic state, but asubstantial proportion of RSA, up to 40%, are due to unexplained or unknown etiologies. The complex etiology made RSA one of diseases to be treated difficulty and a hot spots in the present clinical research work.