非酒精性脂肪肝与血液中总胆固醇、三酰甘油、低密度脂蛋白胆固醇的相关性研究

目的 探讨非酒精性脂肪肝（NAFLD）与血液中总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）的相关性,为临床诊断和治疗提供参考依据.方法 选择无脂肪肝的80例中青年正常男性作为对照组,80例中青年男性有NAFLD但不合并2型糖尿病患者作为单纯NAFLD组（A组）,80例中青年男性有NAFLD且合并2型糖尿病者作为NAFLD合并2型糖尿病组（B组）,对三组的血脂进行分析比较.结果 对照组TC、TG、LDL-C分别为（4.09±1.01）,（1.94±2.14）,（2.47±0.93） mmol/L,A组分别为（5.16±2.13）,（3.01±1.56）,（3.15±1.12） mmol/L,B组分别为（6.21±1.17）,（4.35±1.20）,（3.21±0.15） mmol/L,三组比较差异有统计学意义（P＜0.05）,且A、B组TC、TG、LDL-C显著高于对照组,B组TC、TG、LDL-C显著高于A组,差异均有统计学意义（P＜0.05）.结论 NAFLD与血脂密切相关,影响了人体部分脂代谢功能的正常运转,且合并有2型糖尿病的患者脂代谢显著异常.

The research of relation between non-alcoholic fatty liver disease and total cholesterol,triglyceride,low density lipoprotein-cholesterol in blood

Objective To investigate the relation between non-alcoholic fatty liver disease （NAFLD） and total cholesterol （TC）,triglyceride （TG）,low density lipoprotein-cholesterol （LDL-C） in blood,and provide reference for clinical diagnosis and treatment.Methods Eighty cases of normal young men without NAFLD were as control group,80 cases of NAFLD without type 2 diabetes mellitus were as group A,and 80 cases of NAFLD combined with type 2 diabetes mellitus were as group B.Then the blood lipid was analyzed and compared among the 3 groups.Results The TC,TG and LDL-C levels in control group were （4.09 ± 1.01）,（1.94 ±2.14） and （2.47 ±0.93） mmol/L respectively,in group A were （5.16 ±2.13）,（3.01 ± 1.56） and （3.15 ± 1.12） mmol/L respectively,and in group B were （6.21 ± 1.17）,（4.35 ± 1.20）and （3.21 ± 0.15） mmol/L respectively,there were statistical differences among the 3 groups （P ＜ 0.05）.The TC,TG and LDL-C levels in group A and group B were significantly higher than those in control group,in group B were significantly higher than those in group A,and there were statistical differences （P ＜ 0.05）.Conclusions NAFLD and blood lipids is closely related,and it affects normal operation function of part lipid metabolism.Patients with type 2 diabetes mellitus are significantly abnormal in lipid metabolism.