接种卡介苗对毛细支气管炎日后发展成支气管哮喘的临床研究

目的 观察按计划接种卡介苗对毛细支气管炎患儿日后发展成支气管哮喘的影响.方法 采用回顾性研究和临床随访的方法,选择1995年1月至2002年12月确诊为毛细支气管炎的280例患儿,按计划接种卡介苗者135例（卡介苗接种组）,未按计划接种卡介苗者145例（非卡介苗接种组）,随访3～ 10年,比较两组支气管哮喘发生情况.结果 卡介苗接种组支气管哮喘发生率为17.04％（23/135）,明显低于非卡介苗接种组的40.69％（59/145）,差异有统计学意义（P＜0.01）.结论 婴幼儿毛细支气管炎易发展为儿童支气管哮喘,及时接种卡介苗对其日后支气管哮喘的发生呈现保护作用.

Clinical study of vaccinating BCG vaccine in bronchiolitis developed into child bronchial asthma in the future

Objective To observe the incidence of vaccinating BCG vaccine according to plan in bronchiolitis developed into child bronchial asthma in the future.Methods Using the method of retrospective study and clinical follow-up,chosen 280 children diagnosed with bronchiolitis from January 1995 to December 2002,135 cases were vaccinated BCG vaccine according to plan （vaccinated BCG group）,145 cases were not vaccinated BCG vaccine according to plan （non-vaccinated BCG group）,followed up for 3-10 years,the incidence of bronchial asthma between two groups were compared.Results The incidence of bronchial asthma in vaccinated BCG group was lower than that in non-vaccinated BCG group 17.04%（23/135） vs.40.69%（59/145）],there was significant difference （P〈 0.01）.Conclusions It＆#39;s easy for bronchiolitis developing into bronchial asthma in children.Vaccinating BCG vaccine in time in occurrence of bronchial asthma show a protective effect in the future.