原发性高血压伴发颈动脉粥样硬化患者基质金属蛋白酶不同基因型血脂分析

目的 分析携带不同基质金属蛋白酶（MMP）基因型的原发性高血压（EH）伴发颈动脉粥样硬化（CAS）患者血脂情况.方法 纳入维、汉两个民族488例EH患者,采用聚合酶链反应-限制性片段长度多态性技术测定MMP-2-735 C/T和MMP-3-1171 5A/6A基因多态性,依据是否存在CAS分为CAS组（293例,其中汉族171例,维族122例）和颈动脉正常组（NS组,195例,其中汉族105例,维族90例）,对不同基因型携带者进行血脂分析.结果 对于MMP-2基因,汉族CAS组CT＋TT基因型低密度脂蛋白胆固醇（LDL-C）高于CC基因型（P＜0.05）,高密度脂蛋白胆固醇低于CC基因型（P＜0.05）;维族MMp-2 CT＋ TT基因型三酰甘油均高于CC基因型（P＜0.05）.对于MMP-3基因,汉族NS组6A/6A基因型总胆固醇、LDL-C高于5A/5A＋5A/6A基因型（P＜0.05）.结论 MMP不同基因型患者血脂水平存在差异,与CAS发生机制可能相关.

The analysis of the blood fatty in different genotypes of matrix metalloproteinases in the carotid atherosclerosis patients with essential hypertension

Objective To investigate the blood fatty levels in different genotypes of matrix metalloproteinases （MMP） and the carotid atherosclerosis （CAS） in patients with essential hypertension （EH）.Methods Four hundred and eighty-eight cases of Han and Uygur in patients with EH were selected,and MMP-2-735 C/T and MMP-3-1171 5A/6A polymorphism was measured by polymerase chain reactionrestriction fragment length polymorphism.They were divided into two groups：EH with CAS group （CAS group,293 cases,Han 171 cases,Uygur 122 cases） and EH without CAS group （NS group,195 cases,Han 105 cases,Uygur 90 cases）.Blood fatty factors were analyzed according to the different MMP genotypes.Results According to MMP-2 genotypes,in Hart CAS group,the low density lipoprotein cholesterol （LDL-C） levels in MMP-2 CT＋TT genotypes were significantly higher than those in CC genotype（P ＜ 0.05）,and high density lipoprotein cholesterol levels were significantly lower than those in CC genotype（P ＜ 0.05）; In Uygur CAS group,the triglyceride levels in MMP-2 CT＋TT genotypes were significantly higher than those in CC genotype（P ＜ 0.05）.According to MMP-3 genotypes in Han NS group,the total cholesterol and LDL-C levels in 6A/6A genotype were significantly higher than those in 5A/5A＋5A/6A genotypes （P ＜ 0.05）.Conclusion The blood fatty levels are different in patients with different MMP genotypes,which may probably influence the CAS.