子痫前期孕妇血清和胎盘组织脂联素的表达及意义

目的 分析子痫前期孕妇血清和胎盘组织脂联素的表达及意义.方法 采用酶联免疫吸附法检测52例无妊娠并发症孕妇（对照组）、58例轻度子痫前期孕妇（轻度子痫前期组）、55例重度子痫前期孕妇（重度子痫前期组）血清脂联素,并计算稳态模型评估法胰岛素抵抗指数（HOMA-IR）;采用免疫组织化学SP法检测三组孕妇胎盘组织脂联素表达情况.结果 重度子痫前期组空腹血糖明显高于对照组和轻度子痫前期组（5.56±1.37） mmol/L比（4.55±0.51）,（4.68±0.66） mmol/L],轻度子痫前期组、重度子痫前期组空腹胰岛素及HOMA-IR均高于对照组（14.19±3.42）,（14.90±6.64） mU/L比（9.87±1.75） mU/L,1.04±0.37,1.18±0.56比0.67±0.21],重度子痫前期组血清脂联素明显高于对照组和轻度子痫前期组（15.79±4.86） mg/L比（11.47± 3.50）,（11.92±2.96） mg/L],差异均有统计学意义（P＜0.05）.三组胎盘组织脂联素水平比较差异均无统计学意义（P＞0.05）.血清脂联素水平与HOMA-IR及胎盘组织脂联素表达无相关性（P＞0.05）.结论 重度子痫前期孕妇血清脂联素、HOMA-IR明显增高,血清脂联素升高可能是子痫前期孕妇的一种适当的反馈性调节.

Expression and significance of adiponectin in serum and placenta tissue in preeclampsia pregnancy women

Objective To analyze the expression and significance of adiponectin in serum and placenta tissue in preeclampsia pregnancy women.Methods Serum adiponectin levels were measured by Enzyme-linked immuno sorbent assay （ELISA） in 52 cases of normal pregnant women （control group）,58 cases of mild preeclampsia pregnancy women （mild preeclampsia group）,and 55 cases of severe preeclampsia pregnancy women （severe preeclampsia group）.Insulin resistance was estimated using the homeostatic model assessment-insulin resistance index （HOMA-IR）.The expression of adiponectin in placenta tissue was detected by immunohistochemical SP methods in three groups.Results Fasting glucose level in severe preeclampsia group was higher than that in control group and mild preeclampsia group （5.56 ± 1.37） mmol/L vs.（4.55 ± 0.51）,（4.68 ± 0.66） mmol/L],fasting insulin level and HOMA-IR in mild preeclampsia group and severe preeclampsia group were higher than those in control group （14.19 ±3.42）,（14.90 ±6.64） mU/L vs.（9.87 ± 1.75） mU/L,1.04 ±0.37,1.18 ±0.56 vs.0.67 ±0.21],serum adiponectin level in severe preeclampsia group was higher than that in control group and mild preeclampsia group （15.79 ± 4.86） mg/L vs.（11.47 ±3.50）,（11.92 ± 2.96） mg/L],the differences were statistical significance （P 〈 0.05）.There was no difference of adiponectin expression levels in placenta tissue among three groups （P 〉0.05）.There was no significant correlations between serum adiponectin level and HOMA-IR,expression levels of adiponectin in placenta tissue（P 〉 0.05）.Conclusions Serum adiponectin levels and HOMA-IR are higher in the severe preeclampsia pregnancy women.Increased serum adiponectin levels may be an appropriate feedback regulation in preeclampsia pregnancy women.