Nocturnal sleep in huntington's disease |
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| Authors: | M Wiegand A A Möller C J Lauer S Stolz W Schreiber M Dose J C Krieg |
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| Institution: | (1) Max-Planck-Institut für Psychiatrie, Kraepelinstrasse 10, W-8000 München, Federal Republic of Germany;(2) Psychiatrische Klinik der Technischen Universität, Ismaninger Strasse 22, W-8000 München 80, Federal Republic of Germany;(3) Psychiatrische Klinik der Universität, Hauptstrasse 5, W-7800 Freiburg, Federal Republic of Germany;(4) Bezirkskrankenhaus, Feuchtwanger Strasse 38, W-8800 Ansbach, Federal Republic of Germany |
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| Abstract: | Summary Nocturnal sleep was studied in 16 inpatients with Huntington's disease. In comparison with healthy controls, patients exhibited a disturbed sleep pattern with increased sleep onset latency, reduced sleep efficiency, frequent nocturnal awakenings, more time spent awake and less slow wave sleep. These abnormalities correlated in part with duration of illness, severity of clinical symptoms, and degree of atrophy of the caudate nucleus. Patients showed an increased density of sleep spindles. |
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| Keywords: | Huntington's disease Sleep EEG Basal ganglia disorders |
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