脂联素及高敏C反应蛋白与急性脑梗死预后的相关性研究

目的 探讨急性脑梗死患者血浆脂联素(adiponectin,APN)及高敏C反应蛋白(high-sensitive C-reactive protein,Hs-CRP)水平变化与预后的相关性。方法 147例急性脑梗死患者采用头颅MRI的DWI计算梗死容积,进一步分为大、中、小梗死组,分别在治疗前、治疗第7天、第14天测定APN与Hs-CRP,同时进行临床神经功能损害程度评价,对结果进行分析。结果 随着梗死容积增大,APN降低,Hs-CRP升高,经过治疗逐渐恢复。随着梗死容积增大,NIHSS逐步升高,BI逐渐下降,治疗后NIHSS明显下降而BI明显升高。随着梗死容积增大,APN降低而Hs-CRP升高,同时NIHSS升高而BI降低。APN与NIHSS呈负相关,APN与BI呈正相关,Hs-CRP与NIHSS呈正相关,Hs-CRP与BI呈负相关。结论 血浆APN、Hs-CRP水平与脑梗死病情的严重程度密切相关,定期检查APN、Hs-CRP对评估脑梗死的预后很有价值。

Correlation of Adiponectin and Hs-CRP with the Prognosis of Acute Cerebral Infarction

Objective To investigate the correlation of adiponectin and high-sensitivity CRP(Hs-CRP) with the prognosis of acute cerebral infarction. Methods Totally 147 cases of acute cerebral infarction were divided into big, middle, small groups on the basis of cerebral infarction volume,the volume was calculated according to the DWI of head MRI.The levels of APN and Hs-CRP before and 7,14 days after treatment were measured.The NIHSS, BI scores were evaluated, and the results were carried on the comparative analysis of groups APN and Hs-CRP changes and NIHSS, BI scores. Results When the infarction volume increased,the levels of APN decreased and recovered gradually after treatment.Hs-CRP is the opposite.When the infarction volume increased,NIHSS score gradually increased and BI score decreased, NIHSS score decreased and BI score increased significantly after treatment. When the infarction volume increased, the levels of APN and BI score decreased, while Hs-CRP and NIHSS score increased. APN levels were negatively correlated with NIHSS score. APN levels were positively correlated with BI score, hs-CRP levels were positively correlated with NIHSS score, and hs-CRP was negatively correlated with BI score. Conclusion The level of APN, hs-CRP was closely correlated with the severity of cerebral infarction. Determination of APN and Hs-CRP level regularly is very valuable to assess the prognosis of cerebral infarction.