脑利钠肽与高血压左室肥厚及舒张功能的关系

目的探讨原发性高血压（EH）患者血浆脑利钠肽（BNP）含量及其与左心室肥厚（LVH）、左心室舒张功能（LVDF）的关系。方法采用免疫放射分析法测定122例EH患者和36例对照组血浆BNP浓度;用心脏彩色多普勒超声诊断仪器测定EH患者左室质量指数（LVMI）、左室射血分数（LVEF）和E/A比值。对BNP与LVMI、E/A比值作直线相关分析。结果 EH患者BNP浓度显著高于对照组（P〈0.01）,且EH伴LVH者BNP浓度明显高于EH无LVH者,差异有统计学意义（P〈0.01）;EH伴LVH者血浆BNP浓度与LVMI呈显著正相关（r=0.45,P〈0.01）,与E/A比值呈显著负相关（r=-0.68,P〈0.01）。结论 EH患者血浆BNP水平明显升高,且与LVH、LVDF密切相关;BNP浓度的测定可望成为EH患者LVH及LVDF障碍的一项诊断指标。

Correlation between Serum Brain Natriuretic Peptide Levels and Left Ventricular Hypertrophy, Diastolic Function in Patients with Essential Hypertention

Objective To study the correlation between the serum brain natriuretic peptide（BNP）levels,the left ventricular hypertrophy（LVH）,and left ventricular diastolic function（LVDF）in patients with essential hypertention（EH）.Methods 122 patients with EH and 36 control subjects were investigated by measuring the serum BNP level and the left ventricular mass index（LVMI）,ratio of E/A was determined by two dimensional echocardiography.The correlation between the serum BNP and LVMI,ratio of E/A were analyzed.Results The serum BNP level in patients with EH were markedly higher than those in control subjects（P〈0.01）,furthermore,the serum BNP level was significantly increased（P〈0.01）in hypertensive patients with left ventricular hypertrophy（LVH）as compared with those without LVH.The serum BNP positively correlated with LVMI in patients with EH and negatively correlated with ratio of E/A in patients with EH.Conclusion The extent of BNP increase is closely correlated to the LVH and LVDF,furthermore,the serum BNP level may be a marker for the hypertensive patients with LVH and left ventricular diastolic dysfunction.