| 大剂量氨甲喋呤配合甲酰四氢叶酸钙一次解救治疗的初步应用 |
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| 引用本文： | 秦风展,张家驹,谈承芸,吴书怡,郑荣生,丁永为.大剂量氨甲喋呤配合甲酰四氢叶酸钙一次解救治疗的初步应用[J].蚌埠医学院学报,1986(1). |
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| 作者姓名： | 秦风展 张家驹 谈承芸 吴书怡 郑荣生 丁永为 |
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| 作者单位： | 蚌埠医学院附院肿瘤内科
(秦风展，张家驹，谈承芸，吴书怡，郑荣生)，蚌埠医学院附院肿瘤内科(丁永为) |
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| 摘 要： | 本文对8例晚期癌症患者用大剂量氨甲喋呤(MTX)配合甲酰四氢叶酸钙(CF)一次解救治疗进行了研究。全部患者均采用MTX500mg/m~2,24小时静脉持续点滴,此后一次肌注CF10～12mg/m~2解救。七例可评价疗效患者的总有效率为42.8％。白细胞减少,口腔粘膜溃疡、恶心、呕吐和发热是主要的毒副反应,多呈轻至中度,并在短期内即能恢复。
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| 关 键 词： | 氨甲喋呤 恶性肿瘤 解救 常规化疗剂量 完全缓解 部分缓解 不变 恶化 |
A STUDY OF HD-MTX PLUS CITROVORUM FACTOR (CF) SINGLE BOLUS RESCUE USED IN THE TREATMENT OF CANCER |
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| Qin Fenzhan,et al..A STUDY OF HD-MTX PLUS CITROVORUM FACTOR (CF) SINGLE BOLUS RESCUE USED IN THE TREATMENT OF CANCER[J].Journal of Bengbu Medical College,1986(1). |
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| Authors: | Qin Fenzhan |
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| Abstract: | This report presents HD-MTX plus citrovorumfactor (CF) single
bolus rescue used in the treatment of cancer. The patients were given
MTX 500mg/m2 intravenous infusion over 24 hours and CF single bolus
( 10-12mg/m2 ) in tramuscular following MTX infusion, and the overall
response rate was 42.80% ( especially for malignant lyrrpboma ) .
The chief side-effects of the treatment were leukopenia, oral mucosa ulcer, nausea, vomiting and so on, but most of them were mild-moderate and rapidly disappeared in a short time. |
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| Keywords: | metholrcxate malignant tumour rescue conventional chemotherapeutic dose complete response partial rcsponse no change progressive disease |
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