| 中间体氨化物的纯度及其对氨氯吡咪原料药质量的影响 |
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| 引用本文： | 中间体氨化物的纯度及其对氨氯吡咪原料药质量的影响[J]. 中国药科大学学报, 1995, (4): 203-205. |
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| 作者姓名： | 张胜强 陈建明 |
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| 作者单位： | 中国药科大学药物分析研究室，华瑞制药有限公司，溧阳市制药厂 |
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| 摘 要： | 应用高效液相色谱考察了用于制备氨氯吡咪的中间体３，５－二氨基－６－氯－２－甲氧基－羰基吡嗪（氨化物）的纯度。色谱含量分析与熔点测定结果相互支持，氨化物含量高的粗品有高的熔点。用较高纯度的氨化物制备的氨氯吡咪的质量较高。
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| 关 键 词： | 利尿药 氨吡吡咪 中间体氨化物 纯度 质量控制 |
Purity of Intermediate Ammoniate and Its Influence on Quality of Amiloride |
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| Purity of Intermediate Ammoniate and Its Influence on Quality of Amiloride[J]. Journal of China Pharmaceutical University, 1995, (4): 203-205. |
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| Authors: | zhang Shengqiang Chen Jianmin Yu Wenxian Jiang Xinru |
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| Abstract: | The Purity of 3,5-diamino-6-chlor-2-methoxy-carboyl-pyrazinge(ammoniate),an intermediate of amiloride was examined by HPLC.The chromatographic determination results of crude ammoniates conformed to melting point data.Ammoniate of high purity possessed high melting point.The amiloride prepared with ammoniate of high purity had good quality. |
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| Keywords: | diamino-6-chlor-2-methoxy-carboyl-pyrazinge Purity Amiloride |
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