| 气相色谱法测定人血浆中阿替洛尔含量 |
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| 引用本文： | 气相色谱法测定人血浆中阿替洛尔含量[J]. 中国药科大学学报, 1995, (6): 344-346. |
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| 作者姓名： | 彭建和 涂家生 |
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| 作者单位： | 中国药科大学分析计算中心药剂学教研室，中国药科大学分析计算中心药物分析学教研室 |
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| 摘 要： | 建立了人血浆中阿替洛尔气相色谱测定方法。提取样品经三氟乙酰化，电子捕获检测器检测，最低检测浓度可达５ｎｇ／ｍｌ。方法回收率大于９３％，日内、日间ＲＳＤ分别为２．５％和４．５％，血药浓度在５０￣２００ｎｇ／ｍｌ呈线性关系，ｒ＝０．９９８３６，ｎ＝７。
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| 关 键 词： | 阿替洛尔 血药浓度 气相色谱法 药物代谢动力学 |
Determination of Atenolol in Human Plasma by Gas Chromatography |
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| Determination of Atenolol in Human Plasma by Gas Chromatography[J]. Journal of China Pharmaceutical University, 1995, (6): 344-346. |
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| Authors: | Peng Jianhe Tu Jiasheng Xin Jiudong |
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| Abstract: | The method for determination of atenolol in human plasma by gas chromatography was established. After being extracted from plasma,atenolol is trifluoracetated,and determined by gas chromatography using electron-capture detector(ECD). The lowest determinable concentration,recovery,precision within-day and between days were 5ng/ml,93%, 2.5%and 4.5% respectively.There is a good linear relationship in the plasma concentration ranging from 50 to 200 ng/ml. |
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| Keywords: | Atenolol Gas chromatography Plasma concentration |
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