| 美洛昔康抗炎作用的实验研究 |
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| 引用本文： | 许晖,姚全胜,周国林. 美洛昔康抗炎作用的实验研究[J]. 中国新药杂志, 2001, 10(5): 345-347 |
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| 作者姓名： | 许晖 姚全胜 周国林 |
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| 作者单位： | 江苏省药物研究所药理室, |
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| 摘 要： | 目的观察美洛昔康的抗炎作用。方法采用大鼠急性、亚急性及免疫性炎症模型，观察美洛昔康对角叉菜胶致大鼠足跖肿胀和大鼠棉球肉芽肿的影响以及美洛昔康对大鼠佐剂性关节炎的预防和治疗作用。结果美洛昔康对多种致炎剂引起的炎性水肿均具有明显的抑制作用，1.0和3.0mg
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| 关 键 词： | 美洛昔康；动物炎症模型；抗炎作用 |
| 文章编号： | 1003-3734（2001）05-0345-03 |
| 修稿时间： | 2000-10-09 |
Study on antiinflammatoryeffect of meloxicam in animals |
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| XU Hui,YAO Quan-sheng,ZHOU Guo-lin. Study on antiinflammatoryeffect of meloxicam in animals[J]. Chinese Journal of New Drugs, 2001, 10(5): 345-347 |
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| Authors: | XU Hui YAO Quan-sheng ZHOU Guo-lin |
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| Abstract: | Objective:To study the antiinflammatory effect of meloxicam in animals.Methods:3 kinds of animal model for experimental inflammation,including carrageenin-induced paw edema,cotton-ball granuloma and adjuvant induced arthritis,were adopted to validate the antiinflammable effect of meloxicam.Results:Meloxicam showed a marked inhibitory effect on carrageenin-induced paw edema and cotton-ball granuloma in rats,the inhibitory rate of meloxicam at the dose of 1.0,3.0mg*kg-1 in granuloma model were 36.59% and 52.34% respectively.In addition,meloxicam also showed a significant therapeutic effect on adjuvant induced arthritis in rats and improved the pathological changes of the induced athritis.Conclusion:Meloxicam shows significant antiinflammatory effects on animal models mentioned above. |
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