| 美金刚对阿尔茨海默病患者血清SOD和NSE的影响 |
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| 引用本文： | 董靖德,陆小伟,王小姗,靳凌,李继民. 美金刚对阿尔茨海默病患者血清SOD和NSE的影响[J]. 实用老年医学, 2010, 24(1): 30-32. DOI: 10.3969/j.issn.1003-9198.2010.01.010 |
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| 作者姓名： | 董靖德 陆小伟 王小姗 靳凌 李继民 |
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| 作者单位： | 1. 南京医科大学附属脑科医院老年神经科,江苏省南京市,210029
2. 南京医科大学第一附属医院老年神经科,江苏省南京市,210029 |
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| 摘 要： | 目的通过应用美金刚治疗阿尔茨海默病,探讨血浆超氧化物歧化酶（SOD）和神经元特异性烯醇化酶（NSE）浓度变化与认知功能改善的关系。方法符合美国精神障碍诊断与统计手册第4版诊断标准的阿尔茨海默病（AD）患者67例,随机分为美金刚治疗组和常规治疗组,另外选取对照组39例,在入组前、治疗第1月、3月及6月时,测定其SOD和NSE浓度及进行简易精神状态检查量表（MMSE）评分。结果治疗6月后,美金刚治疗组血清SOD浓度和MMSE评分明显高于常规治疗组,NSE浓度明显低于常规治疗组（P〈0.05）; 治疗6月后,美金刚治疗组血清SOD浓度和MMSE评分明显高于治疗前,NSE浓度明显低于治疗前（P〈0.05）。结论应用美金刚治疗AD可以提高SOD含量,减少NSE生成,减轻氧化应激损伤,取得较好的疗效。
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| 关 键 词： | 阿尔茨海默病 美金刚 超氧化物歧化酶 神经元特异性烯醇化酶 |
Effects of memantine on serum SOD and NSE in patients with Alzheimer's disease |
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| DONG Jing-de,LU Xiao-wei,WANG Xiao-shan,JIN Ling,LI Ji-min. Effects of memantine on serum SOD and NSE in patients with Alzheimer's disease[J]. Practical Geriatrics, 2010, 24(1): 30-32. DOI: 10.3969/j.issn.1003-9198.2010.01.010 |
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| Authors: | DONG Jing-de LU Xiao-wei WANG Xiao-shan JIN Ling LI Ji-min |
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| Affiliation: | DONG Jing-de,WANG Xiao-shan,JIN Ling,LI Ji-min.Department of Geriatric Neurology,the Brain Hospital Affiliated to Nanjing Medical University,Nanjing 210029,China,LU Xiao-wei.Department of Geriatric Neurology,the First Affiliated Hospital of Nanjing Medical University |
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| Abstract: | Objective To observe the effects of memantine on serum SOD and NSE in patients with Alzheimer's disease(AD).Methods Sixty-seven elderly patients with AD were randomly divided into memantine treatment group and routine treatment group.Thirty-nine healthy subjects were chosen as normal group.The serum concentration of SOD was measured by chemical colorimetry.The serum concentration of NSE was measured by enzyme-linked immunosorbent assay(ELISA).Results After 6 months of treatment,the level of serum SOD and th... |
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| Keywords: | Alzheimer's disease memantine superoxide dismutase neuron-specific enolase |
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