| 二巯丙磺钠对小鼠脑缺血再灌注致学习记忆功能障碍的影响 |
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| 引用本文： | 胡国新,周红宇,陈醒言,林丹.二巯丙磺钠对小鼠脑缺血再灌注致学习记忆功能障碍的影响[J].温州医学院学报,2002,32(4):205-206. |
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| 作者姓名： | 胡国新 周红宇 陈醒言 林丹 |
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| 作者单位： | 温州医学院药理教研室,浙江,温州,325027 |
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| 基金项目： | 浙江省教委科研基金项目 (SJ970 0 18) |
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| 摘 要： | 目的：观察二巯丙磺钠（Na-DMPS)对脑缺血再灌注后小鼠记忆功能的保护作用。方法：采用暂时性阻断两侧颈总动脉的方法制备小鼠脑缺血再灌注损伤的模型，测试其被动回避能力及脑内丙二醛（MDA）含量。结果：icv Na-DMPS可延长脑缺血再灌注小鼠的避暗潜伏期，减少错误次数，并降低脑内MDA的含量。结论：Na-DMPS可通过抑制脑内的脂质过氧化反应，而明显减轻脑缺血再灌注导致的小鼠学习记忆功能障碍。
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| 关 键 词： | 二巯丙磺钠 脑缺血 再灌注损伤 学习障碍 记忆障碍 脂质过氧化作用 动物模型 |
| 文章编号： | 1000-2138(2002)04-0205-02 |
| 修稿时间： | 2001年12月31 |
Effect of Na-DMPS on learning and memory disorder by cerebral ischemia reperfusion in mice |
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| HU Guo xing,ZHOU Hong yu,CHEN Xing yan,et al..Effect of Na-DMPS on learning and memory disorder by cerebral ischemia reperfusion in mice[J].Journal of Wenzhou Medical College,2002,32(4):205-206. |
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| Authors: | HU Guo xing ZHOU Hong yu CHEN Xing yan |
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| Institution: | HU Guo xing,ZHOU Hong yu,CHEN Xing yan,et al. Department of Pharmacology,Wenzhou Medical College,325000 |
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| Abstract: | Objective:To study the effects of Na DMPS on learning and memory disorder by cerebral ischemia reperfusion in mice.Methods:Cerebral ischemia reperfusion injury was produced in conscious mice by temporarily obstructing bilateral common carolid arteries. Passive avoidance and the MDA level in mice brain were assessed.Results:Na DMPS icv significantly increased the latencyes and decreased the number of errors in the cerebral ischemia reperfused mice. Meanwhile, Na DMPS icv was found to prevent the rise of MDA level induced by cerebral ischemia reperfusion.Conclusion:Na DMPS was shown to improve the impairment of memory function induced by cerebral ischemia reperfusion, which may be related to its anti oxidation. |
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| Keywords: | cerebral ischemia reperfusion injury Na DMPS learning disorder memory disorder lipid peroxidation |
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