进展性缺血性卒中

进展性卒中在缺血性脑血管病中的发生率较高。研究发现,某些因素与其发生有关,可预测卒中进展的发生,因此干预这些因素可阻止其发生和发展。这些危险因素包括高血糖、高纤维蛋白原、发热、糖尿病史、早期CT局灶性低密度影、大脑中动脉高密度征、临床DWI不匹配,以及兴奋性氨基酸(如谷氨酸)、一些细胞因子(如促炎因子IL6和抗炎因子IL10、IL4)水平异常等。目前一些针对性治疗已进行了临床试验,有望在不久将来可用于临床。

Progressive Ischemic Stroke

The incidence of progressive stroke is higher in ischemic cerebrovascular diseases. Studies have found that some factors are associated with its occurrence and predict occurrence of progressive stroke. Therefore, the intervention of these factors can prevent its occurrence and development. These risk factors include hyperglycemia, high fibrinogen, fever, history of diabetes, focal hypodensity on early CT, hyperdense middle cerebral artery signs, and clinical-DWI mismatch, as well as the abnormal levels in excitatory amino acids (eg, glutamate) and some cytokines (eg, proinflammatory cytokine IL-6 and anti-inflammatory cytokines IL-10, IL-4). Now some intended clinical trials have been performed. It is expected to be applied in clinical practice in the near future.