阿折地平对自发性高血压大鼠左心室肥厚的抑制作用

目的 观察阿折地平对自发性高血压大鼠（spontaneous hypertension rat,SHR）心肌肥厚的抑制作用，初步探讨阿折地平抑制和逆转左心室肥厚(left ventricular hypertrophy, LVH)的可能机制。方法 20只SHR随机分为阿折地平组和SHR组，另选同源同系、血压正常的Wistar Kyoto大鼠10只作为正常对照组( WKY组)，分别给予阿折地平（3mg·kg-1）和生理盐水灌胃，所有大鼠10周后测定收缩压（SBP）、心率（HR）、左心室重量指数(LVW／BW)、血清和心肌组织中一氧化氮（NO）和肿瘤坏死因子（TNF-α）含量。结果 SHR组与WKY组比较，SHR组SBP、LVW／BW 明显升高（P＜0.05），血清和心肌中NO含量明显降低（P＜0.05），TNF-α含量明显升高（P＜0.05）；应用阿折地平治疗10周后，SHR组与阿折地平组比较，阿折地平组SBP、LVW／BW有所升高（P＜0.05），血清和心肌中NO含量明显升高（P＜0.05），TNF-α含量明显降低（P＜0.05）。结论 阿折地平可以抑制高血压大鼠心肌肥厚，机制可能与其升高NO水平，抑制TNF α表达有关。

Inbibitory effect of Azelnidipin on left ventricular hypertrophy in spontaneous hypertension rats

Objective    To explore the inbibitory effect of Azelnidipin on left ventricular hypertrophy in spontaneous hypertension rats(SHRs).  Methods    Twenty healthy SHRs were randomLy divided into the Azelnipin treatment group and the SHR group．At the same time，ten WKY rats( the WKY group) served as the normal control group. Rats in the Azelnidipin group were treated with Azelnidipin for 10 weeks and rats in the SHR and WKY groups were treated with 0.9％ NaCl of the same volume simultaneously. Ten weeks later, SBP, HR and the indexes of LVW／BW, TNF-α and NO were determined. Results    Compared with the WKY group,  SBP, LVW／BW and TNF-α of the SHR  groups had a great increase（P＜0.05）, and meanwhile NO in the serum and myocardium decreased（P＜0.05）. Compared with the SHR group, SBP, LVW/BW and NO in the serum and myocardium of the Azelnidipin group significantly increased（P＜0.05）, while TNF-αdecreased（P＜0.05）. Conclusion     Azelnipin may inhibit left ventricular hypertrophy of SHR, which may be related to the increase of NO and decrease of TNF α.