支气管肺泡灌洗液肿瘤标志物检测对肺癌诊断的价值

目的：探讨支气管肺泡灌洗液（BALF）中3种肿瘤标志物的检测在肺癌诊断及病情评估中的价值。方法：采用电化学发光法、酶联免疫吸附法检测61例确诊的肺癌患者和42例肺良性病变患者BALF中癌胚抗原（CEA）、细胞角蛋白片断19（CYFRA21-1）及神经特异性烯醇化酶（NSE）的含量并进行分析比较。结果：肺癌患者BALF中3种肿瘤标志物的含量均明显高于肺良性病变患者（P〈0．01或P〈0．05）；不同病理类型肺癌中，各肿瘤标志物升高的程度均有所不同，CYFRA21-1在非小细胞肺癌中升高明显，且随着TNM临床分期的升高，其含量亦明显升高。NSE则在小细胞肺癌中升高明显。结论：BALF中3种肿瘤标志物的检测在肺癌的诊断，病理类型的判定及临床分期等方面均有较高的临床价值。

The Value of Determination of Tumor Markers in Bronchoalveolar Lavage Fluid in the Diagnosis of Lung Cancer

Objective: To investigate the value of three tumor markers in bronchoalveolar lavage fluid (BALF) for diagnosis and evalution of disease extent in patients with lung cancer. Methods: The level of CEA , CYFRA21-1 and NSE of BALF were measured and compared in sixty-one patients with lung cancer and forty-two patients with benign lung diseases by using electric chemilluminescent and ELISA methods respectively .The results were compared and analyzed. Results: The level of all three tumor markers in BALF of the lung cancer group were much higher than those in the benign lung disease group (P < 0.01 or P < 0.05).These tumor markers increased in different degrees among the patients in various pathological classifications.CYFRA21-1 significantly increased in non small cell lung cancer and raised with advance of TNM.NSE increased in small cell lung cancer. Conclusion: The measurement of three tumor markers in BALF has more clinical value and contribute to the diagnosis, pathological classification and clinical stages of lung cancer.