| 局部特异性脱敏治疗常年性变应性鼻炎的免疫学观察 |
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| 引用本文： | 祁沁红,浦志成,殷明德. 局部特异性脱敏治疗常年性变应性鼻炎的免疫学观察[J]. 临床耳鼻咽喉头颈外科杂志, 2000, 14(2): 57-59 |
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| 作者姓名： | 祁沁红 浦志成 殷明德 |
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| 作者单位： | 南京医科大学第一附属医院耳鼻咽喉科,南京,210029 |
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| 摘 要： | 目的 :探讨鼻腔局部特异性脱敏 ( LNIT)的疗效和免疫机理。方法 :用 LNIT治疗常年性变应性鼻炎 ( PAR)患者 1 42例 ,并对其中的 30例进行免疫学观察。结果 :LNIT与传统的皮下免疫疗法的疗效相似 ( P >0 .0 5)。免疫观察表明 ,治疗后患者鼻分泌物中的 Ig A显著增加 ( P <0 .0 5) ;鼻分泌物总 Ig E、血清总 Ig E和螨、豚草的特异性 Ig E水平都有所下降 ,但仍无显著差异( P >0 .0 5)。结论 :LNIT确能通过增强局部免疫功能 ,使 PAR的治疗获得较好的效果。
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| 关 键 词： | 脱敏疗法 变应性鼻炎 免疫学 |
The immunologic study on local nasal immunotherapy for perennial allergic rhinitis |
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| QI Qin-hong,PU Zhi-cheng,YIN Ming-de. The immunologic study on local nasal immunotherapy for perennial allergic rhinitis[J]. Journal of clinical otorhinolaryngology, head, and neck surgery, 2000, 14(2): 57-59 |
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| Authors: | QI Qin-hong PU Zhi-cheng YIN Ming-de |
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| Affiliation: | Department of Otorhinolaryngology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029. |
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| Abstract: | Objective:To investigate the clinical efficacy and immune mechanism of local nasal immunotherapy (LNIT).Method:142 cases of perennial allergic rhinitis (PAR) were treated with LNIT.Immunologic study was carried out in 30 cases.Result:LNIT was as effective as traditional subcutaneous immunotherapy (P> 0.05 ).Immunologic study demonstrated ,that the nasal secretory IgA (S IgA) increased significantly after treatment (P< 0.05 ).The levels of nasal secretory total IgE,serum tota IgE and serum specific IgE (anti mite,ragweed pollon) decreased,but there was no significance (P> 0.05 ).Conclusion:LNIT can improve the local immune function and modify the local nasal allergic inflammatory response.It is an effective,safe and convenient treatment. |
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| Keywords: | Nasal cavity Hyposensitization therapy Perennial allergic rhinitis Immunoglobulins |
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