扁桃体炎血清可溶性白细胞介素2受体测定及其临床意义

目的 :观察扁桃体炎血清可溶性白细胞介素 2受体 (SIL- 2 R)水平及其临床意义。方法 :采用 EL ISA双抗夹心法检测 6 8例急慢性扁桃体炎及 6 8例正常人血清 SIL- 2 R水平。结果 :初发急性扁桃体炎及慢性扁桃体炎急性发作期患者 SIL - 2 R水平分别为 (6 42 .2± 87.2 )× 10 3u/ L ,(76 2 .3± 90 .5 )× 10 3u/ L ,均显著高于正常对照组的 (2 85 .5± 49.6 )× 10 3u/ L (P <0 .0 1) ,而且后者高于前者 (P <0 .0 1)。慢性扁桃体炎慢性期与正常对照无显著性差异 (P >0 .0 5 ) ,抗生素治疗 3～ 5 d后有效病例血清 SIL - 2 R明显下降。结论 :血清 SIL - 2 R测定对扁桃体炎诊断及疗效判定有一定意义。

Determination of serumal soluble interleukin-2 receptor levels in patients with tonsillitis

OBJECTIVE: To observe serumal soluble interleukin-2 receptor levels in patients with tonsillitis. METHOD: SIL-2R levels in serum were detected in 68 patients with acute or chronic tonsillitis and 68 normal controls. RESULT: The SIL-2R concentrations in patients with acute tonsillitis and in patients with chronic tonsillitis within attacking period were (642.2 +/- 87.2) x 10(3) U/L and (762.3 +/- 90.5) x 10(3) U/L, respectively. Both were significantly higher than those of the controls (285.5 +/- 49.6) x 10(3) U/L (P < 0.001). Moreover the latter was higher than the former (P < 0.001). There was no difference between the patients with chronic tonsillitis within non-attacking period and the controls (P > 0.05). After treatment of antibiotics for 3-5 days, the SIL-2R Concentrations in serum in valid cases were obviously becoming lower. CONCLUSION: Determination of SIL-2R in serum was valuable for the diagnosis and curative effect judgement of tonsillitis.