| 喉乳头状瘤HPV_(16/18)感染与p53蛋白表达的相关性 |
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| 引用本文： | 褚汉启,EmileReyt. 喉乳头状瘤HPV_(16/18)感染与p53蛋白表达的相关性[J]. 临床耳鼻咽喉头颈外科杂志, 2000, 0(6) |
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| 作者姓名： | 褚汉启 EmileReyt |
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| 作者单位： | 同济医科大学附属同济医院耳鼻咽喉科教研室!武汉,430030,ORL,GrenobleUniversityHospital,LaTronche,France |
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| 摘 要： | 目的 :了解喉乳头状瘤组织内 HPV1 6 / 1 8的感染与抑癌基因 p5 3变异的关系 ,以及 HPV感染在喉乳头状瘤发病中的作用。方法 :采用 PCR和免疫组化技术 ,检测 35例喉乳头状瘤组织中 HPV1 6 / 1 8DNA及 p5 3蛋白的表达。结果 :2 4例组织中检出 HPV1 6 / 1 8DNA(6 8.6 % ) ;19例 p5 3蛋白呈过度表达 (5 4.3% ) ;在 12例中同时检出HPV1 6 / 1 8DNA和 p5 3蛋白过度表达 (34 .3% )。结论 :提示 HPV1 6 / 1 8感染和 p5 3变异与喉乳头状瘤的发生明确相关 ,其内在分子机理及临床意义有待进一步阐明。
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| 关 键 词： | 人乳头状瘤病毒 喉肿瘤 乳头状瘤 p53蛋白 |
Study on the association between HPV_(16/18) and expression of p53 protein in laryngeal papillomas |
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| CHU Han qi E Reyt. Study on the association between HPV_(16/18) and expression of p53 protein in laryngeal papillomas[J]. Journal of clinical otorhinolaryngology, head, and neck surgery, 2000, 0(6) |
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| Authors: | CHU Han qi E Reyt |
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| Affiliation: | CHU Han qi 1 E Reyt 2 |
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| Abstract: | Objective:To understand the relationship between the expression of p53 protein and HPV 16/18 infection in laryngeal papillomas.Method:using PCR and immunohistochemistry techiques examined the paraffin embedded tissues of 35 cases of laryngeal papillomas.Result:showed that HPV 16/18 DNA were found in 24 cases of laryngeal papillomas( 68.8 %);overexpression of p53 protein were detected in 19 cases( 54.3 %);both of HPV 16/18 DNA and overexpression of p53 protein were demonstrated in 12 cases of laryngeal papillomas( 34.3 %).Conclusion:This study suggests that HPV 16/18 infection and p53 gene mutation are associated with pathogenesis of laryngeal papillomas. The relation between HPV infection and p53 mutation in tissues of laryngeal papillomas remains to be clarified. |
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| Keywords: | Human papilloma virus Laryngeal neoplasm Papillomas p53 protein |
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