孟鲁司特钠联合布地奈德吸入治疗中重度哮喘患儿疗效观察

目的探讨孟鲁司特钠联合布地奈德吸入治疗中重度哮喘患儿临床疗效。方法选择该院支气管哮喘患儿共100例,上述患儿随机分为观察组和对照组。对照组给予布地奈德吸入治疗。观察组给予布地奈德吸入联合孟鲁司特治疗。观察两组治疗前和治疗后肺功能及IgE改变情况。结果观察组总有效率为96%;对照组总有效率为80.0%。观察组总有效率高于对照组,差异有统计学意义(P<0.05)。观察组治疗后FEV1、PEF分别与对照组治疗后比较,均高于对照组,差异有统计学意义(P<0.05);观察组治疗后IgE水平低于对照组,差异有统计学意义(P<0.05)。结论孟鲁司特钠联合布地奈德吸入治疗中重度儿童哮喘临床显著,值得借鉴。

Clinical Observation of Montelukast Combined with Budesonide Inhalation Therapy on Children with Moderate and Severe Asthma

Objective To explore the clinical efficacy of montelukast combined with budesonide inhalation therapy on children with moderate and severe asthma. Methods 100 children with bronchial asthma was selected and divided into observation group and control group, inhaled budesonide was given to control group, budesonide inhalation combined with montelukast was used to observation group, pulmonary function and IgE changes in two groups were observed before and after treatment. Results The total effective rate in the observation group was 96%; The total effective rate in the control group was 80%.the total effective rate in the observation group was higher than that in the control group, the difference was statistically significant （P〈0.05）. FEV1, PEF in the observation group after treatment compared with those in the control group respectively ,the difference was statistically significant （P〈0.05）; IgE level in the treatment group was lower than that in the control group after treatment,the difference was statistically significant（P〈0.05）. Conclusion Montelukast Combined with budesonide inhalation on moderate and severe asthma in children has significantly clinical efficacy, and that is worth to draw lessons from.