Rapacuronium |
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Authors: | Wierda J M |
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Affiliation: | Department of Anaesthesiology, University Hospital, P.O. Box 30.001, 9700 RB Groningen, The Netherlands. j.m.k.h.wierda@med.rug.nl |
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Abstract: | Rapacuronium (Org 9487; ED90 = 1 mg x kg(-1)) is a new, low potency, short-acting, non-depolarizing neuromuscular blocking agent. An intubating dose of 1.5xED90 or 1.5 mg x kg(-1) of rapacuronium offers acceptable intubating conditions within 60-90 s in most patients. A complete block from this dose can be reversed immediately with satisfactory recovery in 12-16 min. Side-effects are dose-related and are mainly haemodynamic, i.e. an increase in heart rate and a decrease in blood pressure. |
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