Characterization of the disposition of lutein after i.v. administration to rats |
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Authors: | Itagaki Shirou Ogura Wakako Sato Yuki Noda Toshihiro Hirano Takeshi Mizuno Satoshi Iseki Ken |
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Affiliation: | Department of Clinical Pharmaceutics and Therapeutics, Graduate School of Pharmaceutical Sciences, Hokkaido University, sapporo, Japan. |
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Abstract: | Lutein is a carotenoid that has antioxidant effects. Although lutein has received much attention recently due to its antioxidant activities, little information about the pharmacokinetic properties of lutein is available. The disposition of lutein after i.v. administration has not been investigated because lutein is now used as a supplement. The present study was undertaken to acquire additional data on the disposition of lutein after i.v. administration. After i.v. administration, lutein is preferentially distributed to the liver, spleen and lung. Intravenous administration of lutein may provide effective antioxidant activities in these tissues, not only the eye. The results of this study should provide valuable data for drug development. |
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