树突状细胞在肺腺癌组织中的浸润及其影响

目的：研究肺腺癌组织中树突状细胞（ＤＣ）的浸润程度及对预后的影响。方法将Ｓ－１００蛋白作为ＤＣ特异性标记物，应用免疫组织化学方法检测肺腺癌组织中ＤＣ分布。结果４６例肺腺癌中，ＤＣ显著浸润者１９例，５年生存率６１％，无或轻度浸润者２７例，５年生存率２１％，低分化腺癌２６例，显著浸润者１０例，５年生存率５７％，轻度浸润者１６例，５年生存率１６％。经Ｌｏｇ－ｒａｎｋ检验，在显著浸润和轻度浸润组二者之间差

Dendritic cell infiltration in lung adenocarcinoma and its effect on prognosis

Objective To study the infiltration degree of dendritic cells in lung adenocarcinoma and its effect on prognosis. Methods S 100 protein was used as the specific marker for dendritic cells,and immunohistochemistry was employed to detect the distribution of dendritic cells in lung adenocarcinoma. Results Among 46 cases of lung adenocarcinoma, 19 were markedly infiltrated by dendritic cells,the five year survival rate being 61%;27 showed slight infiltration,the five year survival rate being 21%.Among the 46 cases of adenocarcinoma, 26 were low differentiated adenocarcinoma, in which 10 were infiltrated markedly by dendritic cells,five year survival rate being 57%;and 16 were slightly infiltrated,five year survival rate being 16%. These data were evaluated with the log rank test,which showed a significant difference between the markedly infiltrated group and the slightly infiltrated group. Conclusion The prognosis of lung adenocarcinoma which markedly infiltrated by dendritic cells is better than that of slightly infiltrated by dendritic cells .