Dexamethasone reduces lung eosinophilia,and VCAM-1 and ICAM-1 expression induced by Sephadex beads in rats |
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Authors: | Ito Akemi Miyake Mio Morishita Masashi Ito Komei Torii Shinpei Sakamoto Tatsuo |
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Affiliation: | Department of Pediatrics, Nagoya University Postgraduate School of Medicine, 65 Tsurumai-cho, Showa, Nagoya 466-8550, Japan. |
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Abstract: | Airway eosinophilia is one of the key pathophysiologic features in asthma. The endothelial adhesion molecules, vascular cell adhesion molecule (VCAM-1) and intercellular adhesion molecule (ICAM-1), have previously been shown to play a crucial role in eosinophil recruitment into the inflamed airway. We have investigated the effects of dexamethasone on eosinophilia into the bronchoalveolar lavage fluid, and the upregulation of VCAM-1 and ICAM-1 expression, measured by immunoblotting, induced by i.v. injection of Sephadex beads into rats. The beads significantly increased the lung eosinophilia, and expression of VCAM-1 and ICAM-1 in the lung. Pretreatment with dexamethasone (0.1 to 2 mg/kg i.p.) strongly inhibited all the airway inflammatory events in a dose-dependent manner. In conclusion, glucocorticoids may be potent inhibitors of lung eosinophilia, at least in part, due to the prevention of the upregulation of VCAM-1 and ICAM-1 expression. |
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Keywords: | Dexamethasone Lung eosinophilia ICAM-1 (intercellular adhesion molecule) Sephadex bead TNF-α (tumor necrosis factor-α) VCAM-1 (vascular cell adhesion molecule) |
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