| 涎腺腺样囊性癌组织中ILK和E-cadherin的表达及意义 |
| |
| 引用本文： | 黄汉,米磊,张斌,张卓,张辉.涎腺腺样囊性癌组织中ILK和E-cadherin的表达及意义[J].口腔颌面外科杂志,2011,21(3):159-162. |
| |
| 作者姓名： | 黄汉 米磊 张斌 张卓 张辉 |
| |
| 作者单位： | 辽宁医学院附属第一医院,辽宁锦州,121001 |
| |
| 基金项目： | 辽宁省教育厅高等学校科学研究项目 |
| |
| 摘 要： | 目的:探讨整合素连接激酶(integrin-linked kinase,ILK)和上皮型钙黏蛋白(E-cadherin)在涎腺腺样囊性癌(salivary adenoid cystic carcinoma,SACC)组织中的表达及其意义。方法:采用免疫组织化学SP法检测ILK和E-cadherin在SACC及正常涎腺组织中的表达。结果:ILK在SACC中表达,ILK的表达与SACC临床病理分型不相关(P>0.05),与TNM分期有关,在发生神经侵犯及远处转移的病例中,ILK的表达明显增加(P<0.05);与正常涎腺组织相比,E-cadherin在SACC中表达下降,差异有统计学意义(P<0.05),E-cadherin表达与不同组织病理学类型有关,且在实体型、发生神经侵犯及远处转移的病例中,E-cadherin表达下降更明显(P<0.05);ILK与E-cadherin的表达呈负相关(r=-0.768,P<0.001)。结论:SACC组织中ILK表达上调而E-cadherin表达降低,有望成为临床判断涎腺腺样囊性癌恶性程度、评估预后的潜在指标。
|
| 关 键 词： | 涎腺腺样囊性癌 整合素连接激酶 上皮型钙黏蛋白 |
Expression of Integrin-linked Kinase and E-cadherin in Salivary Adenoid Cystic Carcinoma |
| |
| HUANG han,MI Lei,ZHANG Bin,ZHANG Zhuo,ZHANG Hui.Expression of Integrin-linked Kinase and E-cadherin in Salivary Adenoid Cystic Carcinoma[J].Chinese Journal of Oral and Maxillofacial Surgery,2011,21(3):159-162. |
| |
| Authors: | HUANG han MI Lei ZHANG Bin ZHANG Zhuo ZHANG Hui |
| |
| Institution: | HUANG han,MI Lei,ZHANG Bin,ZHANG Zhuo,ZHANG Hui(Department of Stomatology,the First Hospital,Liaoning Medical College,Jinzhou 121001,Liaoning Province,China) |
| |
| Abstract: | Objective: To investigate the expression of integrin-linked kinase(ILK) and epithelial-cadherin(E-cadherin) in salivary adenoid cystic carcinoma(SACC) tissues and exploring its clinical significance.Methods: 49 SACC cases and 6 normal salivary gland tissues were examined by immunohistochemistry SP method.Results: ILK expressed in SACC but no relation with clinical pathology(P>0.05),ILK expression had correlated with tumor TNM stage.ILK expression was significantly intensified in nerve invasion and distant m... |
| |
| Keywords: | salivary adenoid cystic carcinoma integrin-linked kinase(ILK) E-cadherin |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
