艾司洛尔对小儿重症手足口病心肌酶的影响

目的：探讨艾司洛尔对小儿重症手足口病（HFMD）心肌酶的影响.方法：将120例重症HFMD患儿随机分为常规治疗组65例和艾司洛尔组55例,选择同期门诊体检健康儿童45名作为正常对照组.常规治疗组予以抗病毒、降颅压、磷酸肌酸钠保护心肌细胞等治疗,艾司洛尔组在常规治疗组基础上加用艾司洛尔.入院时检测乳酸脱氢酶（LDH）、肌酸激酶（CK）、磷酸激酶同工酶（CK-MB）及去甲肾上腺素（NE）.治疗3 d后复查,比较治疗前后心肌酶及NE变化情况.结果：重症HFMD患儿心肌酶及NE均明显高于正常对照组（P〈0.01）.常规治疗组和艾司洛尔组治疗后LDH、CK、CK-MB及NE均较治疗前显著下降（P〈0.01）.2组治疗前上述各指标差异均无统计学意义（P〉0.05）,治疗后艾司洛尔组上述各指标均较常规治疗组显著下降（P〈0.01）.结论：艾司洛尔治疗小儿重症HFMD能有效减轻心肌损伤.

Influence of esmolol on myocardial enzymes in children with severe hand-foot-mouth disease

Objective：To explore the influence of esmolol on the myocardial enzymes in children with severe hand-foot-mouth disease （HFMD）. Methods：One hundred and twenty cases of severe HFMD were randomly divided into routine therapy group （65 cases） and esmolol group（55 cases）, and 45 healthy children were selected as normal control. The children in the routine therapy group were given antiviral to reduce the intracranial pressure and creatine phosphate sodium to protect myocardial cells. The children in the esmolol group were administered esmolol in addition to the routine therapy. The lactic dehydrogenase（ LDH）, creatine kinase（ CK）, phosphate kinase isozyme（CK-MB） and norepinephrine（NE） were detected at admission and checked again three days after treatment. The changes of the myocardial enzyme and NE were compared before and after the therapy. Results：The myocardial enzyme and NE were significantly higher in children with severe HFMD than that in the normal control （P 〈 0. O1 ）. In the routine therapy group and the esmolol group, the LDH,CK,CK-MB and NE decreased significantly after treatment（P 〈0.01 ） ;the above indicators in the two groups had no significant differences before treatment（ P 〉 0.05 ）, but decreased significantly in the esmolol group after treatment（ P 〈 0. 01 ）. Conclusions ： The esmolol therapy can effectively reduce the myocardial injury in children with severe HFMD. words