| 西洋参茎叶皂甙对离体家兔胸主动脉条的作用 |
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| 引用本文： | 吴捷,于晓江.西洋参茎叶皂甙对离体家兔胸主动脉条的作用[J].中国药理学与毒理学杂志,1995,9(2):155-156. |
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| 作者姓名： | 吴捷 于晓江 |
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| 作者单位： | 西安医科大学临床药理研究所 |
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| 摘 要： | 西洋参茎叶皂甙对离体家兔胸主动脉条的作用吴捷，于晓江，刘传镐（西安医科大学临床药理研究所，西安７１００６１）西洋参茎叶皂甙（ｓａｐｏｎｉｎｓｏｆＰａｎａｘｑｕｉｎｑｕｅ－ｆｏｌｉｕｍｌｅａｆａｎｄｓｔｅｍ，ＳＰＱ）系从西洋参地上部分提取的总皂甙，具有...
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| 关 键 词： | 皂甙类，西洋参 胸主动脉条 氯化钾 氯化钙 去甲肾上腺素 |
Effects of saponinsof Panax qauoinquefolium leaf and stem on isolated rabbit aortic strips |
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| Abstract: | The effects of saponins of Panaxquinquefolium leaf and stem(SPQ)on the KCl-aCl2 and norepinephrine(NE)-induced contrac-tions of isolated rabbit aortic strips were studied.SPQantagonised the contractions induced by KCl,CaCl2 and NE in a non-competitive manner.Theblockade effect of SPQ on the NE-induced contrac-tion was the same as on the potassium depolarized-in-duced one.To the intracellular Ca2 -dependent compo-nent of NE-induced contraction, SPQ exerted the obvi-ous blockad action only at higher concentration. Theresults suggest that the effect of SPQ blocking theCa2 channel on vascular smooth muscle might be re-lated to the inhibition of Ca2 influx through potentialdependent Ca2 channel and receptor operatedCa2 channel. |
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| Keywords: | saponins Panax quinquefolium thoracic aorta strip potassium chloride cakium chlo-ride norepinephrine |
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