| 前胡丙素对大鼠离体缺血再灌注心脏血流动力学的影响 |
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| 引用本文： | 杨解人,李庆平.前胡丙素对大鼠离体缺血再灌注心脏血流动力学的影响[J].中国药理学与毒理学杂志,1995,9(4):271-273. |
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| 作者姓名： | 杨解人 李庆平 |
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| 作者单位： | 南京医科大学心血管药理学研究室，皖南医学院药理学教研室 |
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| 摘 要： | 在大鼠离体心脏缺血再灌注损伤模型上，研究前胡丙素对缺血再灌注后血流动力学的影响。与缺血组比较，大鼠预先ｉｐ前胡丙素１５ｍｇ·ｋｇ￣（－１），每日２次，共３ｄ，可以减轻大鼠离体心脏缺血再灌注损伤，促进冠脉流出量的恢复；防止左室收缩（ＬＶＳＰ，＋ｄｐ／ｄｔ＿（ｍａｘ））和舒张（－ｄｐ／ｄｔ＿（ｍａｘ））功能的下降；抑制肌酸激酶释放；以上结果与硝苯地平（６０μｇ·ｋｇ￣（－１）ｉｐ，每日２次，共３ｄ）类似，结果表明前胡丙素对心肌缺血再灌注的血流动力学变化有改善作用。
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| 关 键 词： | 前胡丙素，心肌再灌注损伤，肌酸激酶类，血流动力学 |
Effects of praeruptorin C on hemodynamics of isolated rat heart with ischemia-reperfused damage |
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| YANG Jie-Ren,LI Qing-Ping,RAO Man-Ren.Effects of praeruptorin C on hemodynamics of isolated rat heart with ischemia-reperfused damage[J].Chinese Journal of Pharmacology and Toxicology,1995,9(4):271-273. |
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| Authors: | YANG Jie-Ren LI Qing-Ping RAO Man-Ren |
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| Abstract: | Effects of praeruptorinC(Prd-C)onmyocardial reperfusion injury hemodynamics in iso-lated Langendorff's heart of rats were studied.During15 min reperfusion after 50 min global ischemia,Pra-C(15 mg·kg￣(-1) ,ip twice daily for 3 d)could promote the recovery of coronary flow,heart rate,leftventricular pressure,and the maximum rate of rise ofleft ventricular Dressure,depress the release of creatinekinase. These effects were same as those of nifedipine(60 μg·kg￣(-1),ip twice dailv for 3 d before test).Theresults suggest that Pra-C can protect mvocardiumperformance against ischemic reperfused damages. |
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| Keywords: | praeruptorin C myocardialreperfusion injury creatine kinases hemodynamics project supported by the Science Foundation of Educa-tional Commission of Jiangsu Province |
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