Inclusion body myositis: Clinical,biological and ultrastructural study |
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Authors: | J. Julien C.L. Vital J.M. Vallat A. Lagueny D. Sapina |
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Affiliation: | 1. Service de Neurologie, Centre Hospitalo-Universitaire de Bordeaux, Hôpital du Haut-Lévêque, Avenue De Magellan, 33604 Pessac France;2. Centre de Microscopie Electronique, Hôpital Pellegrin, Bordeaux France |
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Abstract: | A 48-year-old patient presented for the past 4 years an amyotrophy of the quadriceps and moderate involvement of the truncal and pelvic girdle muscles. The CK level was elevated (10 times the normal rate) and the EMG revealed a fibrillation pattern on relaxation, myotonic bursts on needle insertion and reduced activity during contraction. The histological study of the muscle biopsy showed nuclear cytoplasmic inclusion bodies and pseudo-myelinic membranes. The case was classified in the inclusion body myositis group. Analysis of the other published cases underlines the variety of the clinical, biological and electromyographical aspects and abnormalities. |
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