The concentration of IgM in the cerebrospinal fluid of neurological patients |
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Authors: | C.J.M. Sindic C.L. Cambiaso A. Depre E.C. Laterre P.L. Masson |
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Affiliation: | 1. Unit of Experimental Medicine, International Institute of Cellular and Molecular Pathology, Université Catholique de Louvain, ICP-7430, 75 avenue Hippocrate, B-1200 Brussels Belgium;2. Laboratoire de Neurochimie, Université Catholique de Louvain, 53, avenue E. Mouier, B-1200 Brussels Belgium |
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Abstract: | The level of IgM was determined by Particle Counting Immunoassay in the cerebrospinal fluid. In non-neurological patients (N = 20) the mean was 97.5 μg/l with the upper reference limit at 380 μg/1. The mean IgM index was 0.021 with the upper reference limit at 0.071. Of 21 patients with stroke, 5 had an IgM index exceeding the reference limit. High levels and indices of IgM were observed in most patients (N = 27) with infectious meningo-encephalitis. In this group, the IgM index was abnormal in about 30% of cases with a normal total protein content, and was more often increased than the IgG index. In multiple sclerosis patients (N = 80), the IgM index was increased in 32%. In this disease very high values of IgM index (> 0.13) were never associated with very high values of IgG index (> 1.8). A significantly higher proportion of males was found in the group of patients with very high values of IgM index (N = 11). No significant influence of the age of onset, the interval between onset and sampling and clinical state was observed. However, of 10 patients with a multiple sclerosis history exceeding 15 years none had an IgM index exceeding the upper reference limit. Four patients with multiple sclerosis had a high IgM index without either an increase of the IgG index or the presence of oligoclonal bands. |
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Keywords: | Cerebrospinal fluid IgM Local biosynthesis Multiple sclerosis |
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